Alloimmune thrombocytopenia (AIT) is an important cause of intrauterine hemorrhagic lesions that result from platelet-antigen incompatibility between mother and foetus. Foetal platelets are destroyed by cross-reactive maternal antibodies that cross the placenta. The most serious complication of AIT is foetal intracranial bleeding that may eventually result in intrauterine death or severe neurological impairments.
Cota, F., Zuppa, A. A., Luciano, R. P. M., Gallini, F., Savarese, I., Alighieri, G., Orchi, C., Romagnoli, C., A severe case of intracranial hemorrhage due to alloimmune thromboytopenia, <<THE JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE>>, 2008; (21): 852-854 [http://hdl.handle.net/10807/22933]
A severe case of intracranial hemorrhage due to alloimmune thromboytopenia
Cota, Francesco;Zuppa, Antonio Alberto;Luciano, Rita Paola Maria;Gallini, Francesca;Savarese, Immacolata;Orchi, Claudia;Romagnoli, Costantino
2008
Abstract
Alloimmune thrombocytopenia (AIT) is an important cause of intrauterine hemorrhagic lesions that result from platelet-antigen incompatibility between mother and foetus. Foetal platelets are destroyed by cross-reactive maternal antibodies that cross the placenta. The most serious complication of AIT is foetal intracranial bleeding that may eventually result in intrauterine death or severe neurological impairments.
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