Abstract: At the time of writing, there are already millions of documented infections worldwide by the novel coronavirus 2019 (2019-nCoV or severe acute respiratory syndrome coronavirus 2 (SARS-CoV2)), with hundreds of thousands of deaths. The great majority of fatal events have been recorded in adults older than 70 years; of them, a large proportion had comorbidities. Since data regarding the epidemiologic and clinical characteristics in neonates and children developing coronavirus disease 2019 (COVID-19) are scarce and originate mainly from one country (China), we reviewed all the current literature from 1 December 2019 to 7 May 2020 to provide useful information about SARS-CoV2 viral biology, epidemiology, diagnosis, clinical features, treatment, prevention, and hospital organization for clinicians dealing with this selected population. Impact: Children usually develop a mild form of COVID-19, rarely requiring high-intensity medical treatment in pediatric intensive care unit.Vertical transmission is unlikely, but not completely excluded.Children with confirmed or suspected COVID-19 must be isolated and healthcare workers should wear appropriate protective equipment.Some clinical features (higher incidence of fever, vomiting and diarrhea, and a longer incubation period) are more common in children than in adults, as well as some radiologic aspects (more patchy shadow opacities on CT scan images than ground-glass opacities).Supportive and symptomatic treatments (oxygen therapy and antibiotics for preventing/treating bacterial coinfections) are recommended in these patients.

Di Nardo, M., Van Leeuwen, G., Loreti, A., Barbieri, M. A., Guner, Y., Locatelli, F., Ranieri, V. M., A literature review of 2019 novel coronavirus (SARS-CoV2) infection in neonates and children, <<PEDIATRIC RESEARCH>>, 2021; 89 (5): 1101-1108. [doi:10.1038/s41390-020-1065-5] [https://hdl.handle.net/10807/229228]

A literature review of 2019 novel coronavirus (SARS-CoV2) infection in neonates and children

Locatelli, Franco
Penultimo
Writing – Review & Editing
;
2021

Abstract

Abstract: At the time of writing, there are already millions of documented infections worldwide by the novel coronavirus 2019 (2019-nCoV or severe acute respiratory syndrome coronavirus 2 (SARS-CoV2)), with hundreds of thousands of deaths. The great majority of fatal events have been recorded in adults older than 70 years; of them, a large proportion had comorbidities. Since data regarding the epidemiologic and clinical characteristics in neonates and children developing coronavirus disease 2019 (COVID-19) are scarce and originate mainly from one country (China), we reviewed all the current literature from 1 December 2019 to 7 May 2020 to provide useful information about SARS-CoV2 viral biology, epidemiology, diagnosis, clinical features, treatment, prevention, and hospital organization for clinicians dealing with this selected population. Impact: Children usually develop a mild form of COVID-19, rarely requiring high-intensity medical treatment in pediatric intensive care unit.Vertical transmission is unlikely, but not completely excluded.Children with confirmed or suspected COVID-19 must be isolated and healthcare workers should wear appropriate protective equipment.Some clinical features (higher incidence of fever, vomiting and diarrhea, and a longer incubation period) are more common in children than in adults, as well as some radiologic aspects (more patchy shadow opacities on CT scan images than ground-glass opacities).Supportive and symptomatic treatments (oxygen therapy and antibiotics for preventing/treating bacterial coinfections) are recommended in these patients.
2021
Inglese
Di Nardo, M., Van Leeuwen, G., Loreti, A., Barbieri, M. A., Guner, Y., Locatelli, F., Ranieri, V. M., A literature review of 2019 novel coronavirus (SARS-CoV2) infection in neonates and children, <<PEDIATRIC RESEARCH>>, 2021; 89 (5): 1101-1108. [doi:10.1038/s41390-020-1065-5] [https://hdl.handle.net/10807/229228]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/229228
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