Persistent thrombocytopenia is a common complication after allogeneic hematopoietic stem cell transplantation (HSCT). While the use of thrombopoietin receptor agonists was retrospectively investigated in adults, data in pediatric posttransplant thrombocytopenia are lacking. We evaluated the safety and efficacy of eltrombopag in nine children with platelet transfusion-dependent persistent thrombocytopenia after HSCT. Eltrombopag was started at a median of 147 days after allo-SCT and continued for a median period of 64 days, the starting dose being 50 mg per day. The therapy was well tolerated. After a median time of treatment of 36 days, eight patients (88%) reached sustained platelets count >50 000/μL.

Masetti, R., Vendemini, F., Quarello, P., Girardi, K., Prete, A., Fagioli, F., Pession, A., Locatelli, F., Eltrombopag for thrombocytopenia following allogeneic hematopoietic stem cell transplantation in children, <<PEDIATRIC BLOOD & CANCER>>, 2020; 67 (5): 1-4. [doi:10.1002/pbc.28208] [https://hdl.handle.net/10807/228993]

Eltrombopag for thrombocytopenia following allogeneic hematopoietic stem cell transplantation in children

Locatelli, Franco
Ultimo
Writing – Review & Editing
2020

Abstract

Persistent thrombocytopenia is a common complication after allogeneic hematopoietic stem cell transplantation (HSCT). While the use of thrombopoietin receptor agonists was retrospectively investigated in adults, data in pediatric posttransplant thrombocytopenia are lacking. We evaluated the safety and efficacy of eltrombopag in nine children with platelet transfusion-dependent persistent thrombocytopenia after HSCT. Eltrombopag was started at a median of 147 days after allo-SCT and continued for a median period of 64 days, the starting dose being 50 mg per day. The therapy was well tolerated. After a median time of treatment of 36 days, eight patients (88%) reached sustained platelets count >50 000/μL.
2020
Inglese
Masetti, R., Vendemini, F., Quarello, P., Girardi, K., Prete, A., Fagioli, F., Pession, A., Locatelli, F., Eltrombopag for thrombocytopenia following allogeneic hematopoietic stem cell transplantation in children, <<PEDIATRIC BLOOD & CANCER>>, 2020; 67 (5): 1-4. [doi:10.1002/pbc.28208] [https://hdl.handle.net/10807/228993]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/228993
Citazioni
  • ???jsp.display-item.citation.pmc??? 10
  • Scopus 16
  • ???jsp.display-item.citation.isi??? 16
social impact