Childhood cancer survival has improved significantly in the past few decades, reaching rates of 80% or more at 5 years. However, with improved sur-vival, early-and late-occurring complications of che-motherapy and radiotherapy exposure are becoming progressively more evident. Cardiovascular diseases represent the leading cause of non-oncological morbid-ity and mortality in this highly vulnerable population. Therefore, the necessity of reliable, noninvasive screening tools able to early identify cardiac complica-tions early is now pre-eminent in order to implement prevention strategies and mitigate disease progression. Echocardiography, may allow identification of myo-cardial dysfunction, pericardial complications, and valvular heart diseases. However, additional imaging modalities may be necessary in selected cases. This manuscript provides an in-depth review of noninvasive imaging parameters studied in childhood cancer survi-vors. Furthermore, we will illustrate brief surveillance recommendations according to available evidence and future perspectives in this expanding field. (Curr Probl Cardiol 2023;48:101544.)
Camilli, M., Skinner, R., Iannaccone, G., La Vecchia, G., Montone, R. A., Lanza, G. A., Natale, L., Crea, F., Cameli, M., Del Buono, M. G., Lombardo, A., Minotti, G., Cardiac Imaging in Childhood Cancer Survivors: A State-of-the-Art Review, <<CURRENT PROBLEMS IN CARDIOLOGY>>, 2023; 48 (4): 101544-101544. [doi:10.1016/j.cpcardiol.2022.101544] [https://hdl.handle.net/10807/228487]
Cardiac Imaging in Childhood Cancer Survivors: A State-of-the-Art Review
Camilli, Massimiliano;Iannaccone, Giulia;La Vecchia, Giulia;Montone, Rocco Antonio;Lanza, Gaetano Antonio;Natale, Luigi;Crea, Filippo;Del Buono, Marco Giuseppe;Lombardo, Antonella;
2023
Abstract
Childhood cancer survival has improved significantly in the past few decades, reaching rates of 80% or more at 5 years. However, with improved sur-vival, early-and late-occurring complications of che-motherapy and radiotherapy exposure are becoming progressively more evident. Cardiovascular diseases represent the leading cause of non-oncological morbid-ity and mortality in this highly vulnerable population. Therefore, the necessity of reliable, noninvasive screening tools able to early identify cardiac complica-tions early is now pre-eminent in order to implement prevention strategies and mitigate disease progression. Echocardiography, may allow identification of myo-cardial dysfunction, pericardial complications, and valvular heart diseases. However, additional imaging modalities may be necessary in selected cases. This manuscript provides an in-depth review of noninvasive imaging parameters studied in childhood cancer survi-vors. Furthermore, we will illustrate brief surveillance recommendations according to available evidence and future perspectives in this expanding field. (Curr Probl Cardiol 2023;48:101544.)I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.