A straightforward assembly of polysubstituted 1,2-dihydro-3H-pyrrolo[1,2-a]indol-3-ones through a domino palladium-catalyzed reaction of indol-2-ylmethyl acetates with 1,3-dicarbonyl derivatives is described. The key role of the features of the 1,3-dicarbonyls on the reaction outcome has been explored. The employment of 2-methylcyclohexan-1,3-dione as the dicarbonyl source could allow further challenging indole nucleus functionalizations.

Iazzetti, A., Arcadi, A., Dessalvi, S., Fabrizi, G., Goggiamani, A., Marrone, F., Serraiocco, A., Sferrazza, A., Ullah, K., Synthesis of Polysubstituted 1,2-Dihydro-3H-pyrrolo[1,2-a]indol-3-ones through Domino Palladium-Catalyzed Reactions of Indol-2-ylmethyl Acetates with 1,3-Dicarbonyl Derivatives, <<CATALYSTS>>, 2022; 12 (12): 1516-1533. [doi:10.3390/catal12121516] [https://hdl.handle.net/10807/228415]

Synthesis of Polysubstituted 1,2-Dihydro-3H-pyrrolo[1,2-a]indol-3-ones through Domino Palladium-Catalyzed Reactions of Indol-2-ylmethyl Acetates with 1,3-Dicarbonyl Derivatives

Iazzetti, Antonia
Primo
;
2022

Abstract

A straightforward assembly of polysubstituted 1,2-dihydro-3H-pyrrolo[1,2-a]indol-3-ones through a domino palladium-catalyzed reaction of indol-2-ylmethyl acetates with 1,3-dicarbonyl derivatives is described. The key role of the features of the 1,3-dicarbonyls on the reaction outcome has been explored. The employment of 2-methylcyclohexan-1,3-dione as the dicarbonyl source could allow further challenging indole nucleus functionalizations.
2022
Inglese
Iazzetti, A., Arcadi, A., Dessalvi, S., Fabrizi, G., Goggiamani, A., Marrone, F., Serraiocco, A., Sferrazza, A., Ullah, K., Synthesis of Polysubstituted 1,2-Dihydro-3H-pyrrolo[1,2-a]indol-3-ones through Domino Palladium-Catalyzed Reactions of Indol-2-ylmethyl Acetates with 1,3-Dicarbonyl Derivatives, <<CATALYSTS>>, 2022; 12 (12): 1516-1533. [doi:10.3390/catal12121516] [https://hdl.handle.net/10807/228415]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/228415
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