Neonatal lupus syndrome is considered a model of passively acquired autoimmune disease. The first 10 newborns born to mothers with connective tissue disease and positive for anti-SSA/Ro antibodies enrolled in a follow-up program to evaluate the incidence of cardiac, hepatobiliary, hematologic, echoencephalographic, and cutaneous manifestations until 9 months of age are described in this study. No congenital heart block was observed, but only transient rhythm alterations were observed. In all, 1 infant showed typical neonatal lupus syndrome skin lesions at 3 months of age. During the neonatal period, echoencephalographic alterations were found more frequently, whereas at follow-up, hepatic and hematologic alterations were more often observed. In all, 1 baby showed persistent neutropenia. A standard program that enrolls all infants born to mothers with anti-SSA/Ro autoantibodies, who are at risk of developing neonatal lupus syndrome, should also include tests performed some time after birth, as a number of clinical manifestations might appear at a late stage.

Zuppa, A. A., Fracchiolla, A., Cota, F., Gallini, F., Savarese, I., D'andrea, V., Luciano, R. P. M., Romagnoli, C., Infants born to mothers with anti-SSA/Ro autoantibodies: neonatal outcome and follow-up, <<CLINICAL PEDIATRICS>>, 2008; (47): 231-236 [http://hdl.handle.net/10807/22838]

Infants born to mothers with anti-SSA/Ro autoantibodies: neonatal outcome and follow-up

Zuppa, Antonio Alberto;Fracchiolla, Annalisa;Cota, Francesco;Gallini, Francesca;Savarese, Immacolata;D'Andrea, Vito;Luciano, Rita Paola Maria;Romagnoli, Costantino
2008

Abstract

Neonatal lupus syndrome is considered a model of passively acquired autoimmune disease. The first 10 newborns born to mothers with connective tissue disease and positive for anti-SSA/Ro antibodies enrolled in a follow-up program to evaluate the incidence of cardiac, hepatobiliary, hematologic, echoencephalographic, and cutaneous manifestations until 9 months of age are described in this study. No congenital heart block was observed, but only transient rhythm alterations were observed. In all, 1 infant showed typical neonatal lupus syndrome skin lesions at 3 months of age. During the neonatal period, echoencephalographic alterations were found more frequently, whereas at follow-up, hepatic and hematologic alterations were more often observed. In all, 1 baby showed persistent neutropenia. A standard program that enrolls all infants born to mothers with anti-SSA/Ro autoantibodies, who are at risk of developing neonatal lupus syndrome, should also include tests performed some time after birth, as a number of clinical manifestations might appear at a late stage.
Inglese
Zuppa, A. A., Fracchiolla, A., Cota, F., Gallini, F., Savarese, I., D'andrea, V., Luciano, R. P. M., Romagnoli, C., Infants born to mothers with anti-SSA/Ro autoantibodies: neonatal outcome and follow-up, <<CLINICAL PEDIATRICS>>, 2008; (47): 231-236 [http://hdl.handle.net/10807/22838]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/22838
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