Natural killer cells are an essential component of the innate immune system and play a crucial role in immunity against malignancies, without, at difference with T cells, requiring antigen priming or inducing graft-versus-host-disease. Hence, Natural Killer cells can provide a valuable source of allogeneic “off-the-shelf” adoptive therapy and mediate major antileukemia effects, without inducing potentially lethal alloreactivity. Several cell sources have been used for producing and expanding large numbers of clinical-grade natural killer cells. In this review, we will discuss the advantages and challenges of Natural Killer cell-based therapeutic approaches for hematological malignancies, also exploring different strategies to potentiate their clinical application.
Caruso, S., De Angelis, B., Carlomagno, S., Del Bufalo, F., Sivori, S., Locatelli, F., Quintarelli, C., NK cells as adoptive cellular therapy for hematological malignancies: Advantages and hurdles, <<SEMINARS IN HEMATOLOGY>>, 2020; 57 (4): 175-184. [doi:10.1053/j.seminhematol.2020.10.004] [https://hdl.handle.net/10807/228318]
NK cells as adoptive cellular therapy for hematological malignancies: Advantages and hurdles
Locatelli, FrancoPenultimo
Writing – Review & Editing
;
2020
Abstract
Natural killer cells are an essential component of the innate immune system and play a crucial role in immunity against malignancies, without, at difference with T cells, requiring antigen priming or inducing graft-versus-host-disease. Hence, Natural Killer cells can provide a valuable source of allogeneic “off-the-shelf” adoptive therapy and mediate major antileukemia effects, without inducing potentially lethal alloreactivity. Several cell sources have been used for producing and expanding large numbers of clinical-grade natural killer cells. In this review, we will discuss the advantages and challenges of Natural Killer cell-based therapeutic approaches for hematological malignancies, also exploring different strategies to potentiate their clinical application.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.