The cellular and subcellular distribution of S-100 protein was investigated at the ultrastructural level in the rat retina by the immunocytochemical PAP method. S-100 appeared to be localized in the cytoplasm and nucleus of Müller cells, offering conclusive evidence that in the mammalian retina, the protein is confined to glial cells. S-100, as a marker for Müller cells, may be a useful tool in order to study the cytoarchitecture of the retina in normal as well as in pathologic conditions. In addition, the retina may represent a suitable model for further investigation on the biologic role of S-100.
Cocchia, D., Polak, J., Terenghi, G., Battaglia, F., Stolfi, V., Gangitano, C., Michetti, F., Localization of S-100 protein in Müller cells of the retina--2. Electron microscopical immunocytochemistry, <<INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE>>, 1983; 24 (7): 980-984 [http://hdl.handle.net/10807/22824]
Localization of S-100 protein in Müller cells of the retina--2. Electron microscopical immunocytochemistry
Gangitano, Carlo;Michetti, Fabrizio
1983
Abstract
The cellular and subcellular distribution of S-100 protein was investigated at the ultrastructural level in the rat retina by the immunocytochemical PAP method. S-100 appeared to be localized in the cytoplasm and nucleus of Müller cells, offering conclusive evidence that in the mammalian retina, the protein is confined to glial cells. S-100, as a marker for Müller cells, may be a useful tool in order to study the cytoarchitecture of the retina in normal as well as in pathologic conditions. In addition, the retina may represent a suitable model for further investigation on the biologic role of S-100.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
