: Following recent discoveries, diagnostic criteria for paraneoplastic neurological syndromes (PNS) have been recently updated. However, how the criteria impact PNS diagnosis is still unclear. We retrospectively applied the previously existing 2004 criteria (2004-c) and the updated 2021 diagnostic criteria (2021-c) to 74 patients with suspect PNS. The 2021 criteria were highly sensitive (88%) and specific (80%). There was good concordance between the definite PNS group (2004-c) and the definite plus probable PNS group (2021-c). The inter-rater reliability for the 2021-c was excellent. The application of the 2021 criteria improves the diagnosis of patients with PNS.
Campetella, L., Papi, C., Sabatelli, E., Marini, S., Iorio, R., Real-world application of the updated diagnostic criteria for paraneoplastic neurological syndromes, <<JOURNAL OF NEUROIMMUNOLOGY>>, 2022; 372 (372): N/A-N/A. [doi:10.1016/j.jneuroim.2022.577972] [https://hdl.handle.net/10807/227880]
Real-world application of the updated diagnostic criteria for paraneoplastic neurological syndromes
Campetella, Lucia;Papi, Claudia;Sabatelli, Eleonora;Marini, Sofia;Iorio, Raffaele
2022
Abstract
: Following recent discoveries, diagnostic criteria for paraneoplastic neurological syndromes (PNS) have been recently updated. However, how the criteria impact PNS diagnosis is still unclear. We retrospectively applied the previously existing 2004 criteria (2004-c) and the updated 2021 diagnostic criteria (2021-c) to 74 patients with suspect PNS. The 2021 criteria were highly sensitive (88%) and specific (80%). There was good concordance between the definite PNS group (2004-c) and the definite plus probable PNS group (2021-c). The inter-rater reliability for the 2021-c was excellent. The application of the 2021 criteria improves the diagnosis of patients with PNS.
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