: We investigated by immunocytochemistry the expression of the Ca(2+) binding protein S100A2 in 62 cases of laryngeal squamous-cell carcinoma (SCC). S100A2 was detected in 18/19 (95%) low-grade tumors and in 22/43 (51%) high-grade tumors, which were partially keratinizing. The remaining 21/43 (49%) high-grade tumors were non-keratinizing, anaplastic tumors and clearly S100A2-negative. In normal laryngeal squamous epithelium and in laryngeal SCC, S100A2 expression was strictly associated with that of cytokeratins 14 (P = 0.0002) and 17 (P = 0.0021), suggesting an association of S100A2 expression and cell commitment to squamous differentiation. A correlation was found between S100A2 tumor positivity and longer relapse-free (P = 0.0005) and overall (P = 0.0095) survival.
Lauriola, L., Michetti, F., Maggiano, N., Galli, J., Cadoni, G., Scḧafer, B., Heizmann, C., Ranelletti, F., Prognostic significance of the Ca2+ binding protein S100A2 in laryngeal squamous-cell carcinoma, <<INTERNATIONAL JOURNAL OF CANCER>>, 2000; 89 (4): 345-349. [doi:10.1002/1097-0215(20000720)89:4<345::AID-IJC5>3.0.CO;2-T] [https://hdl.handle.net/10807/227582]
Prognostic significance of the Ca2+ binding protein S100A2 in laryngeal squamous-cell carcinoma
Lauriola, LiberoPrimo
;Michetti, Fabrizio;Galli, Jacopo;Cadoni, Gabriella;
2000
Abstract
: We investigated by immunocytochemistry the expression of the Ca(2+) binding protein S100A2 in 62 cases of laryngeal squamous-cell carcinoma (SCC). S100A2 was detected in 18/19 (95%) low-grade tumors and in 22/43 (51%) high-grade tumors, which were partially keratinizing. The remaining 21/43 (49%) high-grade tumors were non-keratinizing, anaplastic tumors and clearly S100A2-negative. In normal laryngeal squamous epithelium and in laryngeal SCC, S100A2 expression was strictly associated with that of cytokeratins 14 (P = 0.0002) and 17 (P = 0.0021), suggesting an association of S100A2 expression and cell commitment to squamous differentiation. A correlation was found between S100A2 tumor positivity and longer relapse-free (P = 0.0005) and overall (P = 0.0095) survival.
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