Chronic inflammation and subsequent tissutal alterations may play a key role in prostate carcinogenesis. In this way, molecular alterations of the suppressor of cytokine signaling 3 (SOCS3), one of the most important inhibitory molecule of inflammatory signal transduction circuitries, could contribute to explain the pleiotropic role of interleukin-6 (IL-6) in this type of cancer.
Pierconti, F., Martini, M., Pinto, F., Cenci, T., Capodimonti, S., Calarco, A., Bassi, P., Larocca, L. M., Epigenetic silencing of SOCS3 identifies a subset of prostate cancer with an aggressive behavior, <<THE PROSTATE>>, 2011; 71 (3): 318-325. [doi:10.1002/pros.21245] [http://hdl.handle.net/10807/2251]
Autori: | ||
Titolo: | Epigenetic silencing of SOCS3 identifies a subset of prostate cancer with an aggressive behavior | |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1002/pros.21245 | |
Data di pubblicazione: | 2011 | |
Abstract: | Chronic inflammation and subsequent tissutal alterations may play a key role in prostate carcinogenesis. In this way, molecular alterations of the suppressor of cytokine signaling 3 (SOCS3), one of the most important inhibitory molecule of inflammatory signal transduction circuitries, could contribute to explain the pleiotropic role of interleukin-6 (IL-6) in this type of cancer. | |
Lingua: | Inglese | |
Rivista: | ||
Citazione: | Pierconti, F., Martini, M., Pinto, F., Cenci, T., Capodimonti, S., Calarco, A., Bassi, P., Larocca, L. M., Epigenetic silencing of SOCS3 identifies a subset of prostate cancer with an aggressive behavior, <<THE PROSTATE>>, 2011; 71 (3): 318-325. [doi:10.1002/pros.21245] [http://hdl.handle.net/10807/2251] | |
Appare nelle tipologie: | Articolo in rivista, Nota a sentenza |