: Cytomegalovirus (CMV) is the most common cause of congenital infection in humans. There are no enough data on long-term outcome of newborns with congenital CMV (cCMV) infection, particularly for those asymptomatic at birth. For this reason, we performed this study to evaluate long-term audiological, visual, neurocognitive, and behavioral outcome in patients with symptomatic and asymptomatic cCMV infection treated with oral Valganciclovir (VGC). Thirty-six newborns with confirmed cCMV infection were evaluated: 12 (33.3%) symptomatic at birth and 24 asymptomatic (66.7%). No one had cognitive impairment. Cognitive assessment scales resulted abnormal in 4/35 patients (11.4%). 11/21 patients (52.4%) achieved abnormal scores in neuropsychological tests. The language evaluation gave pathological results in 6/21 (28.5%) patients. 6/35 patients (17.1%) developed SNHL, all symptomatic at birth except one. None of the 34 patients evaluated developed CMV retinopathy. Our study shows that both symptomatic and asymptomatic newborns with cCMV infection develop long-term sequelae, particularly in the behavioral and communicative areas, independently from the trimester of maternal infection.

Turriziani Colonna, A., Buonsenso, D., Pata, D., Salerno, G., Chieffo, D. P. R., Romeo, D. M., Faccia, V., Conti, G., Molle, F., Baldascino, A., De Waure, C., Acampora, A., Luciano, R. P. M., Santangelo, R., Valentini, P., Long-Term Clinical, Audiological, Visual, Neurocognitive and Behavioral Outcome in Children With Symptomatic and Asymptomatic Congenital Cytomegalovirus Infection Treated With Valganciclovir, <<FRONTIERS IN MEDICINE>>, 2020; 7 (July): 1-7. [doi:10.3389/fmed.2020.00268] [https://hdl.handle.net/10807/223519]

Long-Term Clinical, Audiological, Visual, Neurocognitive and Behavioral Outcome in Children With Symptomatic and Asymptomatic Congenital Cytomegalovirus Infection Treated With Valganciclovir

Turriziani Colonna, Arianna;Buonsenso, Danilo;Salerno, Gilda;Romeo, Domenico Marco;Conti, Guido;Molle, Fernando;Baldascino, Antonio;De Waure, Chiara;Acampora, Anna;Luciano, Rita Paola Maria;Santangelo, Rosaria;Valentini, Piero
2020

Abstract

: Cytomegalovirus (CMV) is the most common cause of congenital infection in humans. There are no enough data on long-term outcome of newborns with congenital CMV (cCMV) infection, particularly for those asymptomatic at birth. For this reason, we performed this study to evaluate long-term audiological, visual, neurocognitive, and behavioral outcome in patients with symptomatic and asymptomatic cCMV infection treated with oral Valganciclovir (VGC). Thirty-six newborns with confirmed cCMV infection were evaluated: 12 (33.3%) symptomatic at birth and 24 asymptomatic (66.7%). No one had cognitive impairment. Cognitive assessment scales resulted abnormal in 4/35 patients (11.4%). 11/21 patients (52.4%) achieved abnormal scores in neuropsychological tests. The language evaluation gave pathological results in 6/21 (28.5%) patients. 6/35 patients (17.1%) developed SNHL, all symptomatic at birth except one. None of the 34 patients evaluated developed CMV retinopathy. Our study shows that both symptomatic and asymptomatic newborns with cCMV infection develop long-term sequelae, particularly in the behavioral and communicative areas, independently from the trimester of maternal infection.
Inglese
Turriziani Colonna, A., Buonsenso, D., Pata, D., Salerno, G., Chieffo, D. P. R., Romeo, D. M., Faccia, V., Conti, G., Molle, F., Baldascino, A., De Waure, C., Acampora, A., Luciano, R. P. M., Santangelo, R., Valentini, P., Long-Term Clinical, Audiological, Visual, Neurocognitive and Behavioral Outcome in Children With Symptomatic and Asymptomatic Congenital Cytomegalovirus Infection Treated With Valganciclovir, <<FRONTIERS IN MEDICINE>>, 2020; 7 (July): 1-7. [doi:10.3389/fmed.2020.00268] [https://hdl.handle.net/10807/223519]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/223519
Citazioni
  • ???jsp.display-item.citation.pmc??? 11
  • Scopus 12
  • ???jsp.display-item.citation.isi??? ND
social impact