The mammalian target of rapamycin (mTOR) is a major regulator of skeletal myocyte viability. The signaling pathways triggered by mTOR vary according to the type of endogenous and exogenous factors (e.g., redox balance, nutrient availability, physical activity) as well as organismal age. Here, we provide an overview of mTOR signaling in skeletal muscle, with a special focus on the role played by mTOR in the development of sarcopenia. Intervention strategies targeting mTOR in sarcopenia (e.g., supplementation of plant extracts, hormones, inorganic ions, calorie restriction, and exercise) have also been discussed.

Sirago, G., Picca, A., Calvani, R., Coelho-Junior, H. J., Marzetti, E., Mammalian Target of Rapamycin (mTOR) Signaling at the Crossroad of Muscle Fiber Fate in Sarcopenia, <<INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES>>, 2022; 23 (22): 1-12. [doi:10.3390/ijms232213823] [https://hdl.handle.net/10807/223136]

Mammalian Target of Rapamycin (mTOR) Signaling at the Crossroad of Muscle Fiber Fate in Sarcopenia

Calvani, Riccardo;Marzetti, Emanuele
2022

Abstract

The mammalian target of rapamycin (mTOR) is a major regulator of skeletal myocyte viability. The signaling pathways triggered by mTOR vary according to the type of endogenous and exogenous factors (e.g., redox balance, nutrient availability, physical activity) as well as organismal age. Here, we provide an overview of mTOR signaling in skeletal muscle, with a special focus on the role played by mTOR in the development of sarcopenia. Intervention strategies targeting mTOR in sarcopenia (e.g., supplementation of plant extracts, hormones, inorganic ions, calorie restriction, and exercise) have also been discussed.
Inglese
Sirago, G., Picca, A., Calvani, R., Coelho-Junior, H. J., Marzetti, E., Mammalian Target of Rapamycin (mTOR) Signaling at the Crossroad of Muscle Fiber Fate in Sarcopenia, <<INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES>>, 2022; 23 (22): 1-12. [doi:10.3390/ijms232213823] [https://hdl.handle.net/10807/223136]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/223136
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