Aims: We assessed the outcome of hospitalized coronavirus disease 2019 (COVID-19) patients with heart failure (HF) compared with patients with other cardiovascular disease and/or risk factors (arterial hypertension, diabetes, or dyslipidaemia). We further wanted to determine the incidence of HF events and its consequences in these patient populations. Methods and results: International retrospective Postgraduate Course in Heart Failure registry for patients hospitalized with COVID-19 and CArdioVascular disease and/or risk factors (arterial hypertension, diabetes, or dyslipidaemia) was performed in 28 centres from 15 countries (PCHF-COVICAV). The primary endpoint was in-hospital mortality. Of 1974 patients hospitalized with COVID-19, 1282 had cardiovascular disease and/or risk factors (median age: 72 [interquartile range: 62–81] years, 58% male), with HF being present in 256 [20%] patients. Overall in-hospital mortality was 25% (n = 323/1282 deaths). In-hospital mortality was higher in patients with a history of HF (36%, n = 92) compared with non-HF patients (23%, n = 231, odds ratio [OR] 1.93 [95% confidence interval: 1.44–2.59], P < 0.001). After adjusting, HF remained associated with in-hospital mortality (OR 1.45 [95% confidence interval: 1.01–2.06], P = 0.041). Importantly, 186 of 1282 [15%] patients had an acute HF event during hospitalization (76 [40%] with de novo HF), which was associated with higher in-hospital mortality (89 [48%] vs. 220 [23%]) than in patients without HF event (OR 3.10 [2.24–4.29], P < 0.001). Conclusions: Hospitalized COVID-19 patients with HF are at increased risk for in-hospital death. In-hospital worsening of HF or acute HF de novo are common and associated with a further increase in in-hospital mortality.

Sokolski, M., Trenson, S., Sokolska, J. M., D'Amario, D., Meyer, P., Poku, N. K., Biering-Sorensen, T., Hojbjerg Lassen, M. C., Skaarup, K. G., Barge-Caballero, E., Pouleur, A. -., Stolfo, D., Sinagra, G., Ablasser, K., Muster, V., Rainer, P. P., Wallner, M., Chiodini, A., Heiniger, P. S., Mikulicic, F., Schwaiger, J., Winnik, S., Cakmak, H. A., Gaudenzi, M., Mapelli, M., Mattavelli, I., Paul, M., Cabac-Pogorevici, I., Bouleti, C., Lilliu, M., Minoia, C., Dauw, J., Costa, J., Celik, A., Mewton, N., Montenegro, C. E. L., Matsue, Y., Loncar, G., Marchel, M., Bechlioulis, A., Michalis, L., Dorr, M., Prihadi, E., Schoenrath, F., Messroghli, D. R., Mullens, W., Lund, L. H., Rosano, G. M. C., Ponikowski, P., Ruschitzka, F., Flammer, A. J., Heart failure in COVID-19: the multicentre, multinational PCHF-COVICAV registry, <<ESC HEART FAILURE>>, 2021; 8 (6): 4955-4967. [doi:10.1002/ehf2.13549] [https://hdl.handle.net/10807/220407]

Heart failure in COVID-19: the multicentre, multinational PCHF-COVICAV registry

D'Amario, D.;
2021

Abstract

Aims: We assessed the outcome of hospitalized coronavirus disease 2019 (COVID-19) patients with heart failure (HF) compared with patients with other cardiovascular disease and/or risk factors (arterial hypertension, diabetes, or dyslipidaemia). We further wanted to determine the incidence of HF events and its consequences in these patient populations. Methods and results: International retrospective Postgraduate Course in Heart Failure registry for patients hospitalized with COVID-19 and CArdioVascular disease and/or risk factors (arterial hypertension, diabetes, or dyslipidaemia) was performed in 28 centres from 15 countries (PCHF-COVICAV). The primary endpoint was in-hospital mortality. Of 1974 patients hospitalized with COVID-19, 1282 had cardiovascular disease and/or risk factors (median age: 72 [interquartile range: 62–81] years, 58% male), with HF being present in 256 [20%] patients. Overall in-hospital mortality was 25% (n = 323/1282 deaths). In-hospital mortality was higher in patients with a history of HF (36%, n = 92) compared with non-HF patients (23%, n = 231, odds ratio [OR] 1.93 [95% confidence interval: 1.44–2.59], P < 0.001). After adjusting, HF remained associated with in-hospital mortality (OR 1.45 [95% confidence interval: 1.01–2.06], P = 0.041). Importantly, 186 of 1282 [15%] patients had an acute HF event during hospitalization (76 [40%] with de novo HF), which was associated with higher in-hospital mortality (89 [48%] vs. 220 [23%]) than in patients without HF event (OR 3.10 [2.24–4.29], P < 0.001). Conclusions: Hospitalized COVID-19 patients with HF are at increased risk for in-hospital death. In-hospital worsening of HF or acute HF de novo are common and associated with a further increase in in-hospital mortality.
Inglese
Sokolski, M., Trenson, S., Sokolska, J. M., D'Amario, D., Meyer, P., Poku, N. K., Biering-Sorensen, T., Hojbjerg Lassen, M. C., Skaarup, K. G., Barge-Caballero, E., Pouleur, A. -., Stolfo, D., Sinagra, G., Ablasser, K., Muster, V., Rainer, P. P., Wallner, M., Chiodini, A., Heiniger, P. S., Mikulicic, F., Schwaiger, J., Winnik, S., Cakmak, H. A., Gaudenzi, M., Mapelli, M., Mattavelli, I., Paul, M., Cabac-Pogorevici, I., Bouleti, C., Lilliu, M., Minoia, C., Dauw, J., Costa, J., Celik, A., Mewton, N., Montenegro, C. E. L., Matsue, Y., Loncar, G., Marchel, M., Bechlioulis, A., Michalis, L., Dorr, M., Prihadi, E., Schoenrath, F., Messroghli, D. R., Mullens, W., Lund, L. H., Rosano, G. M. C., Ponikowski, P., Ruschitzka, F., Flammer, A. J., Heart failure in COVID-19: the multicentre, multinational PCHF-COVICAV registry, <<ESC HEART FAILURE>>, 2021; 8 (6): 4955-4967. [doi:10.1002/ehf2.13549] [https://hdl.handle.net/10807/220407]
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