Here we describe the case of a 30-year-old man with a diagnosis of de novo acute monoblastic leukemia (FAB M5a), whose karyotype analysis revealed the presence of the translocation (8;21)(q22;q22) as the sole chromosome anomaly. In spite of the rather good prognosis patients suffering from acute leukemia and carrying this translocation are supposed to have, our patient had a very poor outcome, including an early relapse resistant to any treatment and meningeal localization. Death occurred within 5 months from diagnosis. To our knowledge this is the first report of t(8;21)(q22;q22) in de novo acute monoblastic leukemia.
Coxfroncillo, M., Genuardi, M., Bajer, J., Livdi, E., Adorno, G., Venditti, A., Masi, M. C., Giudiceandrea, P., Neri, G., Papa, G., FIRST REPORT OF T(8-21)(Q22-Q22) IN A CASE OF DE-NOVO ACUTE MONOBLASTIC LEUKEMIA, <<CANCER GENETICS AND CYTOGENETICS>>, 1995; 79 (1): 82-85 [https://hdl.handle.net/10807/219930]
FIRST REPORT OF T(8-21)(Q22-Q22) IN A CASE OF DE-NOVO ACUTE MONOBLASTIC LEUKEMIA
Genuardi, Maurizio;Masi, Maria Claudia;
1995
Abstract
Here we describe the case of a 30-year-old man with a diagnosis of de novo acute monoblastic leukemia (FAB M5a), whose karyotype analysis revealed the presence of the translocation (8;21)(q22;q22) as the sole chromosome anomaly. In spite of the rather good prognosis patients suffering from acute leukemia and carrying this translocation are supposed to have, our patient had a very poor outcome, including an early relapse resistant to any treatment and meningeal localization. Death occurred within 5 months from diagnosis. To our knowledge this is the first report of t(8;21)(q22;q22) in de novo acute monoblastic leukemia.
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