The occurrence of more than one brain tumor in a single patient is not new, resulting from RT- or CT-induced neoplasms, syndromes or casual association. We report on the exceptional case of a 12-year-old boy harboring three different brain tumors with no definite correlation. The first MRI showed a medulloblastoma with signs of infratentorial and supratentorial tumor spreading, including a small frontal mass. Despite the good response to surgical and adjuvant treatment, the frontal mass remained unchanged and was excised, revealing a lipoastrocytoma. Finally, the possible local recurrence of the original medulloblastoma was a pilocytic astrocytoma with post-radiation alterations. Explanations of this very unusual association include radio-induced tumors, second tumors developing from remnants of medulloblastoma cancer stem cells, or the changing histology after adjuvant therapy. © 2010 International Society of Neuropathology.

Massimi, L., Caldarelli, M., D'alessandris, Q. G., Rollo, M., Lauriola, L., Giangaspero, F., Rocco, C. D., 12-year-old boy with multiple brain masses: Case of month january 2010, <<BRAIN PATHOLOGY>>, 2010; 20 (3): 679-682. [doi:10.1111/j.1750-3639.2010.00381.x] [https://hdl.handle.net/10807/219371]

12-year-old boy with multiple brain masses: Case of month january 2010

Massimi;L.; Caldarelli;M.; D'Alessandris;Q. G.; Rollo;M.; Lauriola;
2010

Abstract

The occurrence of more than one brain tumor in a single patient is not new, resulting from RT- or CT-induced neoplasms, syndromes or casual association. We report on the exceptional case of a 12-year-old boy harboring three different brain tumors with no definite correlation. The first MRI showed a medulloblastoma with signs of infratentorial and supratentorial tumor spreading, including a small frontal mass. Despite the good response to surgical and adjuvant treatment, the frontal mass remained unchanged and was excised, revealing a lipoastrocytoma. Finally, the possible local recurrence of the original medulloblastoma was a pilocytic astrocytoma with post-radiation alterations. Explanations of this very unusual association include radio-induced tumors, second tumors developing from remnants of medulloblastoma cancer stem cells, or the changing histology after adjuvant therapy. © 2010 International Society of Neuropathology.
Inglese
Massimi, L., Caldarelli, M., D'alessandris, Q. G., Rollo, M., Lauriola, L., Giangaspero, F., Rocco, C. D., 12-year-old boy with multiple brain masses: Case of month january 2010, <<BRAIN PATHOLOGY>>, 2010; 20 (3): 679-682. [doi:10.1111/j.1750-3639.2010.00381.x] [https://hdl.handle.net/10807/219371]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/219371
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