POEMS syndrome is a rare paraneoplastic condition, with a poorly understood pathogenesis. High dose chemotherapy followed by autologous stem cell transplantation (ASCT) has been reported to be an effective therapeutic option for patients with good performance status. Here, we review the role of ASCT for POEMS syndrome and discuss indications together with advantages and disadvantages, and related issues such lenalidomide given before or after ASCT, VEGF levels as a marker of disease, and different regimens for stem cell mobilization.
Sora', F., Autologus peripheral blood stem cell transplantation and the role of lenalidomide in patients affected by poem syndrome., <<HEMATOLOGY ONCOLOGY NEWS & ISSUES>>, 2018; (36): 392-398 [https://hdl.handle.net/10807/218064]
Autologus peripheral blood stem cell transplantation and the role of lenalidomide in patients affected by poem syndrome.
Sora', Federica
Penultimo
Membro del Collaboration Group
2018
Abstract
POEMS syndrome is a rare paraneoplastic condition, with a poorly understood pathogenesis. High dose chemotherapy followed by autologous stem cell transplantation (ASCT) has been reported to be an effective therapeutic option for patients with good performance status. Here, we review the role of ASCT for POEMS syndrome and discuss indications together with advantages and disadvantages, and related issues such lenalidomide given before or after ASCT, VEGF levels as a marker of disease, and different regimens for stem cell mobilization.
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