Different strategies have been investigated for a more satisfactory treatment of advanced breast cancer, including the adjuvant use of omega-3 polyunsaturated fatty acids (PUFAs). These nutritional compounds have been shown to possess potent anti-inflammatory and antiangiogenic activities, the capacity to affect transduction pathways/receptors involved in cell growth and to reprogram tumor microenvironment. Omega-3 PUFA-containing nanoformulations designed for drug delivery in breast cancer were shown to potentiate the effects of enclosed drugs, enhance drug delivery to target sites, and minimize drug-induced side effects. We have critically analyzed here the results of the most recent studies investigating the effects of omega-3 PUFA-containing nanoformulations in breast cancer. The anti-neoplastic efficacy of omega-3 PUFAs has also been convincingly demonstrated by using preclinical in vivo models of ovarian cancer. The results obtained are critically analyzed here and seem to provide a sufficient rationale to move to still lacking interventional clinical trials, as well as to evaluate possible advantages of enclosing omega-3 PUFAs to drug-delivery nanosystems for ovarian cancer. Future perspectives in this area are also provided.

Serini, S., Cassano, R., Curcio, F., Trombino, S., Calviello, G., Nutraceutical-Based Nanoformulations for Breast and Ovarian Cancer Treatment, <<INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES>>, 2022; 23 (19): 12032-N/A. [doi:10.3390/ijms231912032] [http://hdl.handle.net/10807/217631]

Nutraceutical-Based Nanoformulations for Breast and Ovarian Cancer Treatment

Serini, S.
Primo
;
Calviello, G.
Ultimo
2022

Abstract

Different strategies have been investigated for a more satisfactory treatment of advanced breast cancer, including the adjuvant use of omega-3 polyunsaturated fatty acids (PUFAs). These nutritional compounds have been shown to possess potent anti-inflammatory and antiangiogenic activities, the capacity to affect transduction pathways/receptors involved in cell growth and to reprogram tumor microenvironment. Omega-3 PUFA-containing nanoformulations designed for drug delivery in breast cancer were shown to potentiate the effects of enclosed drugs, enhance drug delivery to target sites, and minimize drug-induced side effects. We have critically analyzed here the results of the most recent studies investigating the effects of omega-3 PUFA-containing nanoformulations in breast cancer. The anti-neoplastic efficacy of omega-3 PUFAs has also been convincingly demonstrated by using preclinical in vivo models of ovarian cancer. The results obtained are critically analyzed here and seem to provide a sufficient rationale to move to still lacking interventional clinical trials, as well as to evaluate possible advantages of enclosing omega-3 PUFAs to drug-delivery nanosystems for ovarian cancer. Future perspectives in this area are also provided.
Inglese
Serini, S., Cassano, R., Curcio, F., Trombino, S., Calviello, G., Nutraceutical-Based Nanoformulations for Breast and Ovarian Cancer Treatment, <<INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES>>, 2022; 23 (19): 12032-N/A. [doi:10.3390/ijms231912032] [http://hdl.handle.net/10807/217631]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/217631
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