A protocol for Cardiac Autonomic Nervous System Evaluation (CANSE) was used to quantify the degree of dysautonomia in Parkinson disease (PD) and Multisystem Atrophy (MSA) patients (pts). Methods: 14 pts, 12 with PD, 2 with MSA and 14 normal controls (NC) studied. Neurological derangement quantified with UPDR III and Hoehn/Yahr scales (HYS). CANSE performed according to the 5-tests Ewing Score (ES) [0-1/10 (normal), 2-4/10 (borderline), 5-10/10 (abnormal)] and with and Heart Rate Variability analysis (HRV), carried out in the time-domain (TD) and frequency-domain (FD), calculated in 5-minutes intervals during sleep and activity from 24h ECG Holter recordings. Results: only for HYS evidenced significantly higher value in MSA as compared with PD (p< 0.01). ES was higher in MSA (mean score 5.5) compared with PD (2.88), PD + diabetes (3.66) and NC (1.5). SDNN index and r-MSSD (p< 0.05) were abnormal in PD+MSA. Total Power, LF-HF components and LF/HF ratio were abnormal in PD/MSA. Higher ES and HRV abnormality correlated with neurological derangement. Conclusions: CANSE provides accurate assessment of ANS derangement in PD/MDA pts, useful to guide clinical and drugs management
Fenici, R., Brisinda, D., Sorbo, A., Venuti, A., Di Giacopo, R., Bentivoglio, A. R., CARDIAC AUTONOMIC NERVOUS SYSTEM EVALUATION IN PARKINSON DISEASE AND MULTISYSTEM ATROPHY: VALUE OF HRV, Abstract de <<Venice Arrhythmias 2011>>, (Venezia, 09-12 October 2011 ), <<JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY>>, 2011; 22 (1, SI): S66-S66 [http://hdl.handle.net/10807/21549]
CARDIAC AUTONOMIC NERVOUS SYSTEM EVALUATION IN PARKINSON DISEASE AND MULTISYSTEM ATROPHY: VALUE OF HRV
Fenici, Riccardo;Brisinda, Donatella;Di Giacopo, Raffaella;
2011
Abstract
A protocol for Cardiac Autonomic Nervous System Evaluation (CANSE) was used to quantify the degree of dysautonomia in Parkinson disease (PD) and Multisystem Atrophy (MSA) patients (pts). Methods: 14 pts, 12 with PD, 2 with MSA and 14 normal controls (NC) studied. Neurological derangement quantified with UPDR III and Hoehn/Yahr scales (HYS). CANSE performed according to the 5-tests Ewing Score (ES) [0-1/10 (normal), 2-4/10 (borderline), 5-10/10 (abnormal)] and with and Heart Rate Variability analysis (HRV), carried out in the time-domain (TD) and frequency-domain (FD), calculated in 5-minutes intervals during sleep and activity from 24h ECG Holter recordings. Results: only for HYS evidenced significantly higher value in MSA as compared with PD (p< 0.01). ES was higher in MSA (mean score 5.5) compared with PD (2.88), PD + diabetes (3.66) and NC (1.5). SDNN index and r-MSSD (p< 0.05) were abnormal in PD+MSA. Total Power, LF-HF components and LF/HF ratio were abnormal in PD/MSA. Higher ES and HRV abnormality correlated with neurological derangement. Conclusions: CANSE provides accurate assessment of ANS derangement in PD/MDA pts, useful to guide clinical and drugs management
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