The stria vascularis (SV) of 3-, 8- and 18-month-old C57 mice was examined with a fluorescence microscope in order to evaluate the capillary density and vessel diameter. The capillary density was significantly reduced in 18-month-old mice compared to 3-month-old (P<0.001) and to 8-month-old (.P<0.001) mice. The difference between 3- and 18-month-old mice was significant for the basal, middle and apical cochlear turns, while the difference between 8- and 18-month-old mice was significant only for the middle and basal turns. Vessel diameter within the whole SV was significantly reduced in all turns in 18-month-old mice (P<0.01) versus 3-month-old animals, while vessel diameter was reduced only in the basal turn in 8-month-old versus 3-month-old mice. The results suggest that previously described histopathological changes in the organ of Corti of C57 mice may be related to modifications of strial capillaries.

Di Girolamo, S., Quaranta, N., Picciotti, P. M., Torsello, A., Wolf Minotti, F., Age-related Histopathological Changes of the Stria Vascularis: An Experimental Model: Cambios histopat??logicos relacionados con la edad en la estr??a vascular: Un modelo experimental, <<AUDIOLOGY>>, 2001; 2001 (6): 322-326. [doi:10.3109/00206090109073129] [http://hdl.handle.net/10807/214909]

Age-related Histopathological Changes of the Stria Vascularis: An Experimental Model: Cambios histopat??logicos relacionados con la edad en la estr??a vascular: Un modelo experimental

Picciotti, Pasqualina Maria;Wolf Minotti, Federica
2001

Abstract

The stria vascularis (SV) of 3-, 8- and 18-month-old C57 mice was examined with a fluorescence microscope in order to evaluate the capillary density and vessel diameter. The capillary density was significantly reduced in 18-month-old mice compared to 3-month-old (P<0.001) and to 8-month-old (.P<0.001) mice. The difference between 3- and 18-month-old mice was significant for the basal, middle and apical cochlear turns, while the difference between 8- and 18-month-old mice was significant only for the middle and basal turns. Vessel diameter within the whole SV was significantly reduced in all turns in 18-month-old mice (P<0.01) versus 3-month-old animals, while vessel diameter was reduced only in the basal turn in 8-month-old versus 3-month-old mice. The results suggest that previously described histopathological changes in the organ of Corti of C57 mice may be related to modifications of strial capillaries.
Inglese
Di Girolamo, S., Quaranta, N., Picciotti, P. M., Torsello, A., Wolf Minotti, F., Age-related Histopathological Changes of the Stria Vascularis: An Experimental Model: Cambios histopat??logicos relacionados con la edad en la estr??a vascular: Un modelo experimental, <<AUDIOLOGY>>, 2001; 2001 (6): 322-326. [doi:10.3109/00206090109073129] [http://hdl.handle.net/10807/214909]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/214909
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