Benign paroxysmal positional vertigo (BPPV) usually has a favorable course, although it is possible to observe BPPV with a high recurrence rate. Previous studies suggested that vitamin D deficiency might affect BPPV recurrences, and oxidative stress might play a complementary role in BPPV pathogenesis. This multicentric trial aimed to evaluate the effectiveness of oral nutritional supplementation with a compound of alpha-lipoic acid, Carnosine, and Zinc (LICA (R) (Difass International, Coriano (RN), Italy)), vitamins of group B and vitamin D in preventing BPPV recurrences. A total of 128 patients with high recurrence-BPPV were randomized in three arms: Arm 1 consisted of subjects with "insufficient" or "deficient" vitamin D blood levels, treated with daily oral supplementation of LICA (R), vitamins of group B and vitamin D3 (800 UI), Arm 2 included BPPV subjects with "sufficient" vitamin D who did not receive any nutritional support, and Arm 3 included subjects with a "sufficient" serum concentration of vitamin D who received supplementation with a compound of LICA (R) and Curcumin. After six months of follow-up, a significant reduction of BPPV relapses compared to the baseline was found only in Arm 1 (-2.32, 95% CI: 3.41-1.62, p-value < 0.0001). Study results suggested that oral nutritional supplementation with vitamin D3 plus antioxidants can prevent relapses in patients suffering from high recurrence-BPPV.

Libonati, G. A., Leone, A., Martellucci, S., Gallo, A., Albera, R., Lucisano, S., Bavazzano, M., Chiarella, G., Viola, P., Galletti, F., Freni, F., Ciodaro, F., Marcelli, V., Tortoriello, G., Di Santillo, L. S., Picciotti, P. M., Galli, J., Vitale, S., Quaranta, N., Cavallaro, G., Gamba, P., Teggi, R., Cangiano, I., Faralli, M., Barboni, A., Messina, A., Graziano, G., Prevention of Recurrent Benign Paroxysmal Positional Vertigo: The Role of Combined Supplementation with Vitamin D and Antioxidants, <<AUDIOLOGY RESEARCH>>, 2022; 12 (4): 445-456. [doi:10.3390/audiolres12040045] [http://hdl.handle.net/10807/214746]

Prevention of Recurrent Benign Paroxysmal Positional Vertigo: The Role of Combined Supplementation with Vitamin D and Antioxidants

Picciotti, Pasqualina Maria;Galli, Jacopo;
2022

Abstract

Benign paroxysmal positional vertigo (BPPV) usually has a favorable course, although it is possible to observe BPPV with a high recurrence rate. Previous studies suggested that vitamin D deficiency might affect BPPV recurrences, and oxidative stress might play a complementary role in BPPV pathogenesis. This multicentric trial aimed to evaluate the effectiveness of oral nutritional supplementation with a compound of alpha-lipoic acid, Carnosine, and Zinc (LICA (R) (Difass International, Coriano (RN), Italy)), vitamins of group B and vitamin D in preventing BPPV recurrences. A total of 128 patients with high recurrence-BPPV were randomized in three arms: Arm 1 consisted of subjects with "insufficient" or "deficient" vitamin D blood levels, treated with daily oral supplementation of LICA (R), vitamins of group B and vitamin D3 (800 UI), Arm 2 included BPPV subjects with "sufficient" vitamin D who did not receive any nutritional support, and Arm 3 included subjects with a "sufficient" serum concentration of vitamin D who received supplementation with a compound of LICA (R) and Curcumin. After six months of follow-up, a significant reduction of BPPV relapses compared to the baseline was found only in Arm 1 (-2.32, 95% CI: 3.41-1.62, p-value < 0.0001). Study results suggested that oral nutritional supplementation with vitamin D3 plus antioxidants can prevent relapses in patients suffering from high recurrence-BPPV.
Inglese
Libonati, G. A., Leone, A., Martellucci, S., Gallo, A., Albera, R., Lucisano, S., Bavazzano, M., Chiarella, G., Viola, P., Galletti, F., Freni, F., Ciodaro, F., Marcelli, V., Tortoriello, G., Di Santillo, L. S., Picciotti, P. M., Galli, J., Vitale, S., Quaranta, N., Cavallaro, G., Gamba, P., Teggi, R., Cangiano, I., Faralli, M., Barboni, A., Messina, A., Graziano, G., Prevention of Recurrent Benign Paroxysmal Positional Vertigo: The Role of Combined Supplementation with Vitamin D and Antioxidants, <<AUDIOLOGY RESEARCH>>, 2022; 12 (4): 445-456. [doi:10.3390/audiolres12040045] [http://hdl.handle.net/10807/214746]
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