Millions of patients worldwide suffer from end-stage liver pathologies, whose only curative therapy is liver transplantation (OLT). Given the donor organ shortage, alternatives to OLT have been evaluated, including cell therapies. Hepatocyte transplantation has been attempted to cure metabolic liver disorders and end-stage liver diseases. The evaluation of its efficacy is complicated by the shortage of human hepatocytes and their difficult expansion and cryopreservation. Recent advances in cell biology have led to the concept of "regenerative medicine", based on the therapeutic potential of stem cells (SCs). Different types of SCs are theoretically eligible for liver cell replacement. These include embryonic and fetal SCs, induced pluripotent cells, annex SCs, endogenous liver SCs, and extrahepatic adult SCs. Aim of this paper is to critically analyze the possible sources of SCs suitable for liver repopulation and the results of the clinical trials that have been published until now.

Piscaglia, A. C., Campanale, M., Gasbarrini, A., Gasbarrini, G. B., Stem cell-based therapies for liver diseases: state of the art and new perspectives., <<STEM CELLS INTERNATIONAL>>, 2010; 2010 (Settembre): 1-10 [http://hdl.handle.net/10807/21439]

Stem cell-based therapies for liver diseases: state of the art and new perspectives.

Piscaglia, Anna Chiara;Campanale, Mariachiara;Gasbarrini, Antonio;Gasbarrini, Giovanni Battista
2010

Abstract

Millions of patients worldwide suffer from end-stage liver pathologies, whose only curative therapy is liver transplantation (OLT). Given the donor organ shortage, alternatives to OLT have been evaluated, including cell therapies. Hepatocyte transplantation has been attempted to cure metabolic liver disorders and end-stage liver diseases. The evaluation of its efficacy is complicated by the shortage of human hepatocytes and their difficult expansion and cryopreservation. Recent advances in cell biology have led to the concept of "regenerative medicine", based on the therapeutic potential of stem cells (SCs). Different types of SCs are theoretically eligible for liver cell replacement. These include embryonic and fetal SCs, induced pluripotent cells, annex SCs, endogenous liver SCs, and extrahepatic adult SCs. Aim of this paper is to critically analyze the possible sources of SCs suitable for liver repopulation and the results of the clinical trials that have been published until now.
Inglese
Piscaglia, A. C., Campanale, M., Gasbarrini, A., Gasbarrini, G. B., Stem cell-based therapies for liver diseases: state of the art and new perspectives., <<STEM CELLS INTERNATIONAL>>, 2010; 2010 (Settembre): 1-10 [http://hdl.handle.net/10807/21439]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/21439
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