(1) Background: In our previous study, acute ischemic stroke (AIS) patients showed increased levels of circulating miRNAs (-195-5p and -451a) involved in vascular endothelial growth factor A (VEGF-A) regulation. Here, we evaluated, for the first time, both circulating miRNAs in acute intracerebral hemorrhagic (ICH) patients. (2) Methods: Circulating miRNAs and serum VEGF-A were assessed by real-time PCR and ELISA in 20 acute ICH, 21 AIS patients, and 21 controls. These were evaluated at hospital admission (T0) and after 96 h (T96) from admission. (3) Results: At T0, circulating miRNAs were five-times up-regulated in AIS patients, tending to decrease at T96. By contrast, in the acute ICH group, circulating miRNAs were significantly increased at both T0 and T96. Moreover, a significant decrease was observed in serum VEGF-A levels at T0 in AIS patients, tending to increase at T96. Conversely, in acute ICH patients, the levels of VEGF-A were significantly decreased at both T0 and T96. (4) Conclusions: The absence of a reduction in circulating miRNAs (195-5p and -451a), reported in acute ICH subjects after 96 h from hospital admission, together with the absence of increment of serum VEGF-A, may represent useful biomarkers indicating the severe brain damage status that characterizes acute ICH patients.

Giordano, M., Consiglia Trotta, M., Ciarambino, T., D’amico, M., Schettini, F., Di Sisto, A., D’auria, V., Voza, A., Salvatore Malatino, L., Biolo, G., Mearelli, F., Franceschi, F., Paolisso, G., Elio Adinolfi, L., Circulating miRNA-195-5p and -451a in Patients with Acute Hemorrhagic Stroke in Emergency Department, <<LIFE>>, 2022; (12): 1-11 [http://hdl.handle.net/10807/211588]

Circulating miRNA-195-5p and -451a in Patients with Acute Hemorrhagic Stroke in Emergency Department

Franceschi, Francesco
Supervision
;
2022

Abstract

(1) Background: In our previous study, acute ischemic stroke (AIS) patients showed increased levels of circulating miRNAs (-195-5p and -451a) involved in vascular endothelial growth factor A (VEGF-A) regulation. Here, we evaluated, for the first time, both circulating miRNAs in acute intracerebral hemorrhagic (ICH) patients. (2) Methods: Circulating miRNAs and serum VEGF-A were assessed by real-time PCR and ELISA in 20 acute ICH, 21 AIS patients, and 21 controls. These were evaluated at hospital admission (T0) and after 96 h (T96) from admission. (3) Results: At T0, circulating miRNAs were five-times up-regulated in AIS patients, tending to decrease at T96. By contrast, in the acute ICH group, circulating miRNAs were significantly increased at both T0 and T96. Moreover, a significant decrease was observed in serum VEGF-A levels at T0 in AIS patients, tending to increase at T96. Conversely, in acute ICH patients, the levels of VEGF-A were significantly decreased at both T0 and T96. (4) Conclusions: The absence of a reduction in circulating miRNAs (195-5p and -451a), reported in acute ICH subjects after 96 h from hospital admission, together with the absence of increment of serum VEGF-A, may represent useful biomarkers indicating the severe brain damage status that characterizes acute ICH patients.
Inglese
Giordano, M., Consiglia Trotta, M., Ciarambino, T., D’amico, M., Schettini, F., Di Sisto, A., D’auria, V., Voza, A., Salvatore Malatino, L., Biolo, G., Mearelli, F., Franceschi, F., Paolisso, G., Elio Adinolfi, L., Circulating miRNA-195-5p and -451a in Patients with Acute Hemorrhagic Stroke in Emergency Department, <<LIFE>>, 2022; (12): 1-11 [http://hdl.handle.net/10807/211588]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/211588
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