OBJECTIVE: Non-steroidal anti-inflammatory drugs (NSAID) can induce enteropathy. Aspirin ingestion is associated with a lower small-intestinal inflammation than other NSAID. Faecal calprotectin concentrations have recently been proposed as a simple non-invasive test to identify NSAID enteropathy. The aim of our pilot study was to evaluate calprotectin concentrations in patients on treatment with low-dose aspirin. METHODS: Twenty-two patients on prophylactic treatment with aspirin were recruited. Twenty-five healthy volunteers were enrolled as a control group. Faecal calprotectin concentrations were determined by enzyme-linked immunosorbent assay. Statistical analysis was performed by t-test for unpaired data. RESULTS: The mean faecal calprotectin concentration in patients (57.95+/-44.28 microg/g) did not show significant differences compared with controls (45.76+/-26.45 microg/g; P=0.251). CONCLUSIONS: We found that low-dose aspirin does not induce an increase in faecal calprotectin increase
Montalto, M., Curigliano, V., Santoro, L., Lombardi, M., Covino, M., Cammarota, G., Dalvai, S., D'Onofrio, F., Gasbarrini, A., Gasbarrini, G. B., Prophylactic aspirin therapy does not increase faecal calprotectin concentrations., <<EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY>>, 2006; (Settembre): 965-967 [http://hdl.handle.net/10807/21095]
Prophylactic aspirin therapy does not increase faecal calprotectin concentrations.
Montalto, Massimo;Curigliano, Valentina;Santoro, Luca;Covino, Marcello;Cammarota, Giovanni;Dalvai, Sara;D'Onofrio, Fabio;Gasbarrini, Antonio;Gasbarrini, Giovanni Battista
2006
Abstract
OBJECTIVE: Non-steroidal anti-inflammatory drugs (NSAID) can induce enteropathy. Aspirin ingestion is associated with a lower small-intestinal inflammation than other NSAID. Faecal calprotectin concentrations have recently been proposed as a simple non-invasive test to identify NSAID enteropathy. The aim of our pilot study was to evaluate calprotectin concentrations in patients on treatment with low-dose aspirin. METHODS: Twenty-two patients on prophylactic treatment with aspirin were recruited. Twenty-five healthy volunteers were enrolled as a control group. Faecal calprotectin concentrations were determined by enzyme-linked immunosorbent assay. Statistical analysis was performed by t-test for unpaired data. RESULTS: The mean faecal calprotectin concentration in patients (57.95+/-44.28 microg/g) did not show significant differences compared with controls (45.76+/-26.45 microg/g; P=0.251). CONCLUSIONS: We found that low-dose aspirin does not induce an increase in faecal calprotectin increase
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