BACKGROUND: Few controlled studies assessing choice and duration of antibiotic therapy for small intestinal bacterial overgrowth are available. AIM: To assess efficacy, safety and tolerability of different doses of rifaximin, a broad spectrum non-absorbable antibiotic, for intestinal bacterial overgrowth eradication. METHODS: We enrolled 90 consecutive patients affected by small intestinal bacterial overgrowth. The presence of small intestinal bacterial overgrowth was based on the occurrence of a rise of H2 values >12 p.p.m. above the basal value after 50 g glucose ingestion. Patients were randomized in three 7-day treatment groups: rifaximin 600 mg/day (group 1); rifaximin 800 mg/day (group 2) and rifaximin 1200 mg/day (group 3). Glucose breath test was reassessed 1 month after the end of therapy. Compliance to the treatment and incidence of side-effects were also evaluated. RESULTS: No drop-outs were observed in the three groups. Glucose breath test normalization rate was significantly higher in group 3 (60%) with respect to group 1 (17%; P < 0.001) and group 2 (27%, P < 0.01). No significant differences in patient compliance and incidence of side-effects were found among groups. CONCLUSIONS: Higher doses of rifaximin lead to a significant gain in terms of therapeutic efficacy in small intestinal bacterial overgrowth eradication without increasing the incidence of side-effects.

Lauritano, E. C., Gabrielli, M., Lupascu, A., Santoliquido, A., Nucera, G., Scarpellini, E., Vincenti, F., Cammarota, G., Flore, R. A., Pola, P., Gasbarrini, G. B., Gasbarrini, A., -Rifaximin dose-finding study for the treatment of small intestinal bacterial overgrowth, <<ALIMENTARY PHARMACOLOGY & THERAPEUTICS>>, 2005; (Luglio): 31-35 [http://hdl.handle.net/10807/21078]

-Rifaximin dose-finding study for the treatment of small intestinal bacterial overgrowth

Lauritano, Ernesto Cristiano;Gabrielli, Maurizio;Lupascu, Andrea;Santoliquido, Angelo;Nucera, Gabriella;Cammarota, Giovanni;Flore, Roberto Antonio;Pola, Paolo;Gasbarrini, Giovanni Battista;Gasbarrini, Antonio
2005

Abstract

BACKGROUND: Few controlled studies assessing choice and duration of antibiotic therapy for small intestinal bacterial overgrowth are available. AIM: To assess efficacy, safety and tolerability of different doses of rifaximin, a broad spectrum non-absorbable antibiotic, for intestinal bacterial overgrowth eradication. METHODS: We enrolled 90 consecutive patients affected by small intestinal bacterial overgrowth. The presence of small intestinal bacterial overgrowth was based on the occurrence of a rise of H2 values >12 p.p.m. above the basal value after 50 g glucose ingestion. Patients were randomized in three 7-day treatment groups: rifaximin 600 mg/day (group 1); rifaximin 800 mg/day (group 2) and rifaximin 1200 mg/day (group 3). Glucose breath test was reassessed 1 month after the end of therapy. Compliance to the treatment and incidence of side-effects were also evaluated. RESULTS: No drop-outs were observed in the three groups. Glucose breath test normalization rate was significantly higher in group 3 (60%) with respect to group 1 (17%; P < 0.001) and group 2 (27%, P < 0.01). No significant differences in patient compliance and incidence of side-effects were found among groups. CONCLUSIONS: Higher doses of rifaximin lead to a significant gain in terms of therapeutic efficacy in small intestinal bacterial overgrowth eradication without increasing the incidence of side-effects.
Inglese
Lauritano, E. C., Gabrielli, M., Lupascu, A., Santoliquido, A., Nucera, G., Scarpellini, E., Vincenti, F., Cammarota, G., Flore, R. A., Pola, P., Gasbarrini, G. B., Gasbarrini, A., -Rifaximin dose-finding study for the treatment of small intestinal bacterial overgrowth, <<ALIMENTARY PHARMACOLOGY & THERAPEUTICS>>, 2005; (Luglio): 31-35 [http://hdl.handle.net/10807/21078]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/21078
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