Women affected by polycystic ovary syndrome (PCOS) have an increased risk of cardiovascular disease. We demonstrated that women with PCOS showed an expansion of CD4+CD28null T cells, an aggressive population of T lymphocytes that has been recently associated with recurrent coronary instability and type 2 diabetes mellitus. This sheds new light on possible mechanisms responsible for the higher rate of cardiovascular disease among women with PCOS.
Niccoli, G., Apa, R., Lanzone, A., Liuzzo, G., Spaziani, C., Sagnella, F., Cosentino, N., Moro, F., Martinez, D., Morciano, A., Baca', M., Pazzano, V., Gangale, M. F., Tropea, A., Crea, F., CD4+CD28null T lymphocytes are expanded in young women with polycystic ovary syndrome, <<FERTILITY AND STERILITY>>, 2011; 2011 (Giugno): 2651-2654. [doi:10.1016/j.fertnstert.2011.01.129] [http://hdl.handle.net/10807/2097]
CD4+CD28null T lymphocytes are expanded in young women with polycystic ovary syndrome
Niccoli, Giampaolo;Apa, Rosanna;Lanzone, Antonio;Liuzzo, Giovanna;Spaziani, Cristina;Sagnella, Francesca;Cosentino, Nicola;Moro, Francesca;Martinez, Daniela;Morciano, Andrea;Baca', Marco;Pazzano, Vincenzo;Gangale, Maria Francesca;Tropea, Anna;Crea, Filippo
2011
Abstract
Women affected by polycystic ovary syndrome (PCOS) have an increased risk of cardiovascular disease. We demonstrated that women with PCOS showed an expansion of CD4+CD28null T cells, an aggressive population of T lymphocytes that has been recently associated with recurrent coronary instability and type 2 diabetes mellitus. This sheds new light on possible mechanisms responsible for the higher rate of cardiovascular disease among women with PCOS.
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