OBJECTIVE: The role of Helicobacter pylori infection in metabolic control and gastrointestinal symptoms in type 1 diabetes mellitus (DM1) patients has been debated. The aim of this study was to investigate the prevalence of H pylori, of the more cytotoxic Cag-A-positive strains, and the effects of infection on gastrointestinal symptoms and metabolic control in young DM1 patients. Research Design and Methods. H pylori infection was investigated by using the 13C-urea breath test in 121 DM1 patients (65 males, 56 females; mean age: 15 +/- 6 years) and 147 matched controls. In positive patients, an assay for specific immunoglobulin G against Cag-A was performed. Glycosylated hemoglobin A, daily insulin requirement, and duration of illness were established; a questionnaire concerning the presence of dyspeptic symptoms was administered. RESULTS: No difference in H pylori infection rate between patients and controls was observed. Thirty-four (28.1%) of 121 patients and 43 (29.25%) of 147 controls were infected. Twenty-one patients and 24 controls were positive for Cag-A. Glycosylated hemoglobin A, daily insulin requirement, and duration of illness were not affected by infection nor by Cag-A status. Among gastrointestinal symptoms, only halitosis was related to H pylori infection, but this association disappeared after correction for age. Positive patients with halitosis showed a worse glycemic control than uninfected patients with halitosis. CONCLUSIONS: H pylori infection and Cag-A-positive strains do not affect metabolic control in DM1 patients. With regard to gastrointestinal symptoms studied, H pylori infection, when present in participants with halitosis, seems to predict a worse metabolic control than in H pylori-negative patients with halitosis.

Candelli, M., Rigante, D., Marietti, G., Nista, E. C., Crea, F., Bartolozzi, F., Schiavino, A., Pignataro, G., Gentiloni Silveri, N., Gasbarrini, G. B., Gasbarrini, A., A) Helicobacter pylori, gastrointestinal symptoms, and metabolic control in young type 1 diabetes mellitus patients, <<PEDIATRICS>>, 2003; (111(4pt1)): 800-803 [http://hdl.handle.net/10807/20725]

A) Helicobacter pylori, gastrointestinal symptoms, and metabolic control in young type 1 diabetes mellitus patients

Candelli, Marcello;Rigante, Donato;Marietti, Giovanni;Nista, Enrico Celestino;Crea, Filippo;Schiavino, Alessandra;Pignataro, Giulia;Gentiloni Silveri, Nicolo';Gasbarrini, Giovanni Battista;Gasbarrini, Antonio
2003

Abstract

OBJECTIVE: The role of Helicobacter pylori infection in metabolic control and gastrointestinal symptoms in type 1 diabetes mellitus (DM1) patients has been debated. The aim of this study was to investigate the prevalence of H pylori, of the more cytotoxic Cag-A-positive strains, and the effects of infection on gastrointestinal symptoms and metabolic control in young DM1 patients. Research Design and Methods. H pylori infection was investigated by using the 13C-urea breath test in 121 DM1 patients (65 males, 56 females; mean age: 15 +/- 6 years) and 147 matched controls. In positive patients, an assay for specific immunoglobulin G against Cag-A was performed. Glycosylated hemoglobin A, daily insulin requirement, and duration of illness were established; a questionnaire concerning the presence of dyspeptic symptoms was administered. RESULTS: No difference in H pylori infection rate between patients and controls was observed. Thirty-four (28.1%) of 121 patients and 43 (29.25%) of 147 controls were infected. Twenty-one patients and 24 controls were positive for Cag-A. Glycosylated hemoglobin A, daily insulin requirement, and duration of illness were not affected by infection nor by Cag-A status. Among gastrointestinal symptoms, only halitosis was related to H pylori infection, but this association disappeared after correction for age. Positive patients with halitosis showed a worse glycemic control than uninfected patients with halitosis. CONCLUSIONS: H pylori infection and Cag-A-positive strains do not affect metabolic control in DM1 patients. With regard to gastrointestinal symptoms studied, H pylori infection, when present in participants with halitosis, seems to predict a worse metabolic control than in H pylori-negative patients with halitosis.
Inglese
Candelli, M., Rigante, D., Marietti, G., Nista, E. C., Crea, F., Bartolozzi, F., Schiavino, A., Pignataro, G., Gentiloni Silveri, N., Gasbarrini, G. B., Gasbarrini, A., A) Helicobacter pylori, gastrointestinal symptoms, and metabolic control in young type 1 diabetes mellitus patients, <<PEDIATRICS>>, 2003; (111(4pt1)): 800-803 [http://hdl.handle.net/10807/20725]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/20725
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