Pre-eclampsia (PE) is a common disorder of pregnancy that usually presents with hypertension and proteinuria. The clinical presentation arises from soluble factors released into the maternal circulation from the placenta owing to the stress of syncytiotrophoblast, consequence of defective placentation occurring in the first half of pregnancy. Reduced tolerance of the semiallogeneic fetus by the maternal immune system has been proposed as first trigger leading to poor placentation. We previously observed aberrant expression of human leukocyte antigen (HLA)-DR molecules in the syncytiotrophoblast of a subset of women with PE. Aim of this study was to investigate abnormal expression of circulating HLA-DR in syncytiotrophoblast-derived extracellular vesicles (STBEVs) in women with PE compared to normal pregnant women.

Tersigni, C., Lucchetti, D., Franco, R., Colella, F., Neri, C., Crispino, L., Sgambato, A., Lanzone, A., Scambia, G., Vatish, M., Di Simone, N., CIRCULATING PLACENTAL VESCICLES CARRY HLA-DR IN PRE - ECLAMPSIA : A NEW POTENTIAL MARKER OF THE SYNDROME, <<FRONTIERS IN IMMUNOLOGY>>, 2021; (717879): 1-6 [http://hdl.handle.net/10807/206090]

CIRCULATING PLACENTAL VESCICLES CARRY HLA-DR IN PRE - ECLAMPSIA : A NEW POTENTIAL MARKER OF THE SYNDROME

Tersigni, C;Lucchetti, D;Franco, R;Colella, F;Neri, C;Sgambato, A;Lanzone, A;Scambia, G;Di Simone, N.
2021

Abstract

Pre-eclampsia (PE) is a common disorder of pregnancy that usually presents with hypertension and proteinuria. The clinical presentation arises from soluble factors released into the maternal circulation from the placenta owing to the stress of syncytiotrophoblast, consequence of defective placentation occurring in the first half of pregnancy. Reduced tolerance of the semiallogeneic fetus by the maternal immune system has been proposed as first trigger leading to poor placentation. We previously observed aberrant expression of human leukocyte antigen (HLA)-DR molecules in the syncytiotrophoblast of a subset of women with PE. Aim of this study was to investigate abnormal expression of circulating HLA-DR in syncytiotrophoblast-derived extracellular vesicles (STBEVs) in women with PE compared to normal pregnant women.
Inglese
Tersigni, C., Lucchetti, D., Franco, R., Colella, F., Neri, C., Crispino, L., Sgambato, A., Lanzone, A., Scambia, G., Vatish, M., Di Simone, N., CIRCULATING PLACENTAL VESCICLES CARRY HLA-DR IN PRE - ECLAMPSIA : A NEW POTENTIAL MARKER OF THE SYNDROME, <<FRONTIERS IN IMMUNOLOGY>>, 2021; (717879): 1-6 [http://hdl.handle.net/10807/206090]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/206090
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