The central nervous system is metabolically very demanding and consequently vulnerable to defects of the mitochondrial respiratory chain. While the clinical manifestations and the corre-sponding radiological findings of the brain involvement in mitochondrial diseases (e.g., stroke-like episodes, signal changes of the basal ganglia, cerebral and cerebellar atrophy) are well known, at present there are few data on the spinal-cord abnormalities in these pathologies, in particular in adult subjects. In this study, we present a cross-sectional cohort study on the prevalence and characterization of spinal-cord involvement in adult patients with genetically defined mitochondrial diseases.
Primiano, G., Mariotti, P., Turrini, I., Sancricca, C., Sabino, A., Torraco, A., Carrozzo, R., Servidei, S., Spinal cord involvement in adult mitochondrial diseases: A cohort study, <<LIFE>>, 2021; 12 (1): 5-N/A. [doi:10.3390/life12010005] [http://hdl.handle.net/10807/205615]
Spinal cord involvement in adult mitochondrial diseases: A cohort study
Primiano, G.;Mariotti, P.;Turrini, I.;Sancricca, C.;Servidei, S.Ultimo
2022
Abstract
The central nervous system is metabolically very demanding and consequently vulnerable to defects of the mitochondrial respiratory chain. While the clinical manifestations and the corre-sponding radiological findings of the brain involvement in mitochondrial diseases (e.g., stroke-like episodes, signal changes of the basal ganglia, cerebral and cerebellar atrophy) are well known, at present there are few data on the spinal-cord abnormalities in these pathologies, in particular in adult subjects. In this study, we present a cross-sectional cohort study on the prevalence and characterization of spinal-cord involvement in adult patients with genetically defined mitochondrial diseases.
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