Phytosterols are a kind of plant metabolite belonging to the triterpene family. These compounds are essential biomolecules for human health, and so they must be taken from foods. β-Sitosterol, campesterol, and stigmasterol are the main phytosterols found in plants. Phytosterols have beneficial effects on human health since they are able to reduce plasma cholesterol levels and have antiinflammatory, antidiabetic, and anticancer activities. However, there are many difficulties in obtaining them, since the levels of these compounds produced from plant raw materials are low and their chemical synthesis is not economically profitable for commercial exploitation. A biotechnological alternative for their production is the use of plant cell and hairy root cultures. This review is focused on the biosynthesis of phytosterols and their function in both plants and humans as well as the different biotechnological strategies to increase phytosterol biosynthesis. Special attention is given to describing new methodologies based on the use of recombinant DNA technology to increase the levels of phytosterols.

Miras Moreno, M. B., Sabater-Jara, A. B., Pedreno, M. A., Almagro, L., Bioactivity of Phytosterols and Their Production in Plant in Vitro Cultures, <<JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY>>, 2016; 64 (38): 7049-7058. [doi:10.1021/acs.jafc.6b02345] [http://hdl.handle.net/10807/204102]

Bioactivity of Phytosterols and Their Production in Plant in Vitro Cultures

Miras Moreno, Maria Begona
Primo
;
2016

Abstract

Phytosterols are a kind of plant metabolite belonging to the triterpene family. These compounds are essential biomolecules for human health, and so they must be taken from foods. β-Sitosterol, campesterol, and stigmasterol are the main phytosterols found in plants. Phytosterols have beneficial effects on human health since they are able to reduce plasma cholesterol levels and have antiinflammatory, antidiabetic, and anticancer activities. However, there are many difficulties in obtaining them, since the levels of these compounds produced from plant raw materials are low and their chemical synthesis is not economically profitable for commercial exploitation. A biotechnological alternative for their production is the use of plant cell and hairy root cultures. This review is focused on the biosynthesis of phytosterols and their function in both plants and humans as well as the different biotechnological strategies to increase phytosterol biosynthesis. Special attention is given to describing new methodologies based on the use of recombinant DNA technology to increase the levels of phytosterols.
2016
Inglese
Miras Moreno, M. B., Sabater-Jara, A. B., Pedreno, M. A., Almagro, L., Bioactivity of Phytosterols and Their Production in Plant in Vitro Cultures, <<JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY>>, 2016; 64 (38): 7049-7058. [doi:10.1021/acs.jafc.6b02345] [http://hdl.handle.net/10807/204102]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/204102
Citazioni
  • ???jsp.display-item.citation.pmc??? 23
  • Scopus 90
  • ???jsp.display-item.citation.isi??? 71
social impact