Objective: Strict avoidance of trigger food is the primary management of food protein-induced enterocolitis syndrome (FPIES). No published data are available on active induction of tolerance with oral desensitization (OD) in FPIES. Case Report: We carried out an OD in a 9 and a half years old boy with persistent acute egg FPIES. OD was performed with increasing doses of raw egg every week, starting with an initial dose of 0.2 ml. The boy presented mild and transient gastrointestinal adverse reactions when the 4 ml dose was reached. He could tolerate a whole raw egg in less than 14 months. Conclusions: Even though randomized controlled clinical trials on patients including various phenotypes of FPIES are needed, our experience is encouraging about the possible efficacy and safety of OD in this food allergy.

Miceli Sopo, S., Sinatti, D., Gelsomino, M., Oral desensitization in egg acute food protein-induced enterocolitis syndrome, <<EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES>>, 2021; 25 (18): 5766-5768. [doi:10.26355/eurrev_202109_26794] [http://hdl.handle.net/10807/204083]

Oral desensitization in egg acute food protein-induced enterocolitis syndrome

Miceli Sopo, S.
Conceptualization
;
Sinatti, D.
Writing – Original Draft Preparation
;
Gelsomino, M.
Investigation
2021

Abstract

Objective: Strict avoidance of trigger food is the primary management of food protein-induced enterocolitis syndrome (FPIES). No published data are available on active induction of tolerance with oral desensitization (OD) in FPIES. Case Report: We carried out an OD in a 9 and a half years old boy with persistent acute egg FPIES. OD was performed with increasing doses of raw egg every week, starting with an initial dose of 0.2 ml. The boy presented mild and transient gastrointestinal adverse reactions when the 4 ml dose was reached. He could tolerate a whole raw egg in less than 14 months. Conclusions: Even though randomized controlled clinical trials on patients including various phenotypes of FPIES are needed, our experience is encouraging about the possible efficacy and safety of OD in this food allergy.
Inglese
Miceli Sopo, S., Sinatti, D., Gelsomino, M., Oral desensitization in egg acute food protein-induced enterocolitis syndrome, <<EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES>>, 2021; 25 (18): 5766-5768. [doi:10.26355/eurrev_202109_26794] [http://hdl.handle.net/10807/204083]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/204083
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