Several immunosuppressive drugs are used as steroid-sparing agents in pemphigus vulgaris (PV) treatment, with the aim of reducing the cumulative dose of steroids and minimizing the side effects of long-term steroid treatment. The objective of this study is to evaluate the efficacy and safety of enteric-coated mycophenolate sodium (EC-MPS) as a steroid-sparing agent in PV patients. We performed a retrospective study on PV patients who had attended our dermatology department between October 2004 and December 2010 and who had been treated with a combined therapy of systemic corticosteroids and EC-MPS. In the 16 enrolled patients, the introduction of EC-MPS allowed the tapering of systemic corticosteroids, and in 12 of these patients, complete remission was achieved in the time of observation, on average in 4.3 months. Corticosteroid withdrawal was possible in two patients, and EC-MPS was very well tolerated. No serious adverse events were recorded. EC-MPS is a valid therapeutic opportunity as a steroid-sparing agent in PV patients.

De Simone, C., Caldarola, G., Perino, F., Venier, A., Guerriero, G., Enteric-coated mycophenolate sodium as a steroid-sparing agent in pemphigus treatment: a retrospective study, <<DERMATOLOGIC THERAPY>>, 2012; 25 (2): 219-222. [doi:10.1111/j.1529-8019.2012.01450.x] [http://hdl.handle.net/10807/20383]

Enteric-coated mycophenolate sodium as a steroid-sparing agent in pemphigus treatment: a retrospective study

De Simone, Clara;Caldarola, Giacomo;Perino, Francesca;Venier, Antonio;Guerriero, Giuseppe
2012

Abstract

Several immunosuppressive drugs are used as steroid-sparing agents in pemphigus vulgaris (PV) treatment, with the aim of reducing the cumulative dose of steroids and minimizing the side effects of long-term steroid treatment. The objective of this study is to evaluate the efficacy and safety of enteric-coated mycophenolate sodium (EC-MPS) as a steroid-sparing agent in PV patients. We performed a retrospective study on PV patients who had attended our dermatology department between October 2004 and December 2010 and who had been treated with a combined therapy of systemic corticosteroids and EC-MPS. In the 16 enrolled patients, the introduction of EC-MPS allowed the tapering of systemic corticosteroids, and in 12 of these patients, complete remission was achieved in the time of observation, on average in 4.3 months. Corticosteroid withdrawal was possible in two patients, and EC-MPS was very well tolerated. No serious adverse events were recorded. EC-MPS is a valid therapeutic opportunity as a steroid-sparing agent in PV patients.
2012
Inglese
De Simone, C., Caldarola, G., Perino, F., Venier, A., Guerriero, G., Enteric-coated mycophenolate sodium as a steroid-sparing agent in pemphigus treatment: a retrospective study, <<DERMATOLOGIC THERAPY>>, 2012; 25 (2): 219-222. [doi:10.1111/j.1529-8019.2012.01450.x] [http://hdl.handle.net/10807/20383]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/20383
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