Locally advanced vulvar cancer (LAVC) is a challenging disease, requiring multidisci-plinary management. The aim of this review is to propose an integrated clinical approach including radiotherapy (RT) in the multidisciplinary management of LAVC to customize the treatment. A review of the literature was conducted on PubMed, Scopus, and Cochrane library to acquire all relevant studies on RT in LAVC. Based on the available evidence, RT, with or without concurrent chemotherapy, has a relevant role as adjuvant and exclusive treatment or in the neoadjuvant setting. However, multicentric prospective trials are needed to define the best treatment options based on tumor and patient characteristics. A multidisciplinary and multidimensional assessment can also be useful to identify the most suitable approach, considering patients’ age and comorbidities, in view of a better treatment personalization.
Tagliaferri, L., Lancellotta, V., Casa, C., Fragomeni, S. M., Ferioli, M., Gentileschi, S., Caretto, A. A., Corrado, G., Gui, B., Colloca, G. F., Gambacorta, M. A., Morganti, A. G., Garganese, G., Macchia, G., The radiotherapy role in the multidisciplinary management of locally advanced vulvar cancer: A multidisciplinary vulcan team review, <<CANCERS>>, 2021; 13 (22): 5747-5765. [doi:10.3390/cancers13225747] [http://hdl.handle.net/10807/203182]
The radiotherapy role in the multidisciplinary management of locally advanced vulvar cancer: A multidisciplinary vulcan team review
Tagliaferri, Luca;Fragomeni, Simona Maria;Gentileschi, Stefano;Caretto, Anna Amelia;Corrado, Giacomo;Gui, Benedetta;Colloca, Giuseppe Ferdinando;Gambacorta, Maria Antonietta;Morganti, Alessio Giuseppe;Garganese, Giorgia;Macchia, Gabriella
2021
Abstract
Locally advanced vulvar cancer (LAVC) is a challenging disease, requiring multidisci-plinary management. The aim of this review is to propose an integrated clinical approach including radiotherapy (RT) in the multidisciplinary management of LAVC to customize the treatment. A review of the literature was conducted on PubMed, Scopus, and Cochrane library to acquire all relevant studies on RT in LAVC. Based on the available evidence, RT, with or without concurrent chemotherapy, has a relevant role as adjuvant and exclusive treatment or in the neoadjuvant setting. However, multicentric prospective trials are needed to define the best treatment options based on tumor and patient characteristics. A multidisciplinary and multidimensional assessment can also be useful to identify the most suitable approach, considering patients’ age and comorbidities, in view of a better treatment personalization.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
