Herpes simplex virus-1 (HSV-1) is a ubiquitous DNA virus able to establish a life-long latent infection in host sensory ganglia. Following periodic reactivations, the neovirions usually target the site of primary infection causing recurrent diseases in susceptible individuals. However, reactivated HSV-1 may also reach the brain resulting in severe herpetic encephalitis or in asymptomatic infections. These have been reportedly linked to neurodegenerative disorders, such as Alzheimer's disease (AD), suggesting antiviral preventive or/therapeutic treatments as possible strategies to counteract AD onset and progression. Here, we provide an overview of the AD-like mechanisms driven by HSV-1-infection in neurons and discuss the ongoing trials repurposing anti-herpetic drugs to treat AD as well as preventive strategies aimed at blocking virus infection.

Protto, V., Marcocci, M. E., Miteva, M. T., Piacentini, R., Li Puma, D. D., Grassi, C., Palamara, A. T., De Chiara, G., Role of HSV-1 in Alzheimer's disease pathogenesis: A challenge for novel preventive/therapeutic strategies, <<CURRENT OPINION IN PHARMACOLOGY>>, 2022; 63 (63): N/A-N/A. [doi:10.1016/j.coph.2022.102200] [http://hdl.handle.net/10807/202585]

Role of HSV-1 in Alzheimer's disease pathogenesis: A challenge for novel preventive/therapeutic strategies

Piacentini, Roberto;Li Puma, Domenica Donatella;Grassi, Claudio;
2022

Abstract

Herpes simplex virus-1 (HSV-1) is a ubiquitous DNA virus able to establish a life-long latent infection in host sensory ganglia. Following periodic reactivations, the neovirions usually target the site of primary infection causing recurrent diseases in susceptible individuals. However, reactivated HSV-1 may also reach the brain resulting in severe herpetic encephalitis or in asymptomatic infections. These have been reportedly linked to neurodegenerative disorders, such as Alzheimer's disease (AD), suggesting antiviral preventive or/therapeutic treatments as possible strategies to counteract AD onset and progression. Here, we provide an overview of the AD-like mechanisms driven by HSV-1-infection in neurons and discuss the ongoing trials repurposing anti-herpetic drugs to treat AD as well as preventive strategies aimed at blocking virus infection.
2022
Inglese
Protto, V., Marcocci, M. E., Miteva, M. T., Piacentini, R., Li Puma, D. D., Grassi, C., Palamara, A. T., De Chiara, G., Role of HSV-1 in Alzheimer's disease pathogenesis: A challenge for novel preventive/therapeutic strategies, <<CURRENT OPINION IN PHARMACOLOGY>>, 2022; 63 (63): N/A-N/A. [doi:10.1016/j.coph.2022.102200] [http://hdl.handle.net/10807/202585]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/202585
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