Hydroxyurea is a chemotherapeutic agent used extensively for myeloproliferative disorders. Cutaneous side effects have been described during long-term hydroxyurea treatment. We described the occurrence of multiple squamous cell skin carcinomas in a patient treated with hydroxyurea for chronic myelogenous leukemia. The lesions were removed and the hematological therapy switched to busulfan. In a previously reported case, the development of cutaneous epithelial cancers required the discontinuation of hydroxyurea, in addition to the surgical excision of the neoplastic lesions. Since squamous cell carcinoma is a malignant cutaneous neoplasm that can metastatize, the surveillance of skin changes is advisable during hydroxyurea treatment.

De Simone, C., Guerriero, C., Guidi, B., Rotoli, M., Venier, A., Tartaglione, R., Multiple squamous cell carcinomas of the skin during long-term treatment with hydroxyurea, <<EUROPEAN JOURNAL OF DERMATOLOGY>>, 1998; 8 (2): 114-115 [http://hdl.handle.net/10807/20213]

Multiple squamous cell carcinomas of the skin during long-term treatment with hydroxyurea

De Simone, Clara;Guerriero, Cristina;Rotoli, Maurizio;Venier, Antonio;Tartaglione, Raffaele
1998

Abstract

Hydroxyurea is a chemotherapeutic agent used extensively for myeloproliferative disorders. Cutaneous side effects have been described during long-term hydroxyurea treatment. We described the occurrence of multiple squamous cell skin carcinomas in a patient treated with hydroxyurea for chronic myelogenous leukemia. The lesions were removed and the hematological therapy switched to busulfan. In a previously reported case, the development of cutaneous epithelial cancers required the discontinuation of hydroxyurea, in addition to the surgical excision of the neoplastic lesions. Since squamous cell carcinoma is a malignant cutaneous neoplasm that can metastatize, the surveillance of skin changes is advisable during hydroxyurea treatment.
eng
De Simone, C., Guerriero, C., Guidi, B., Rotoli, M., Venier, A., Tartaglione, R., Multiple squamous cell carcinomas of the skin during long-term treatment with hydroxyurea, <>, 1998; 8 (2): 114-115 [http://hdl.handle.net/10807/20213]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/20213
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