Linear IgA disease is an acquired bullous disease of the skin characterized by linear IgA deposits along the dermal-epidermal junction. Inflammatory bowel diseases have been rarely reported in association with linear IgA disease. We have recently observed a patient suffering from ulcerative colitis who developed a cutaneous bullous eruption that was diagnosed as a linear IgA disease. Foreign antigens penetrating the inflamed bowel mucosa might give rise to the production of autoantibodies cross-reacting with the cutaneous antigens involved in the pathogenesis of linear IgA disease.
De Simone, C., Guerriero, C., Pellicano, R., Linear IgA disease and ulcerative colitis, <<EUROPEAN JOURNAL OF DERMATOLOGY>>, 1997; 8 (1): 48-50 [http://hdl.handle.net/10807/20188]
Linear IgA disease and ulcerative colitis
De Simone, Clara;Guerriero, Cristina;
1997
Abstract
Linear IgA disease is an acquired bullous disease of the skin characterized by linear IgA deposits along the dermal-epidermal junction. Inflammatory bowel diseases have been rarely reported in association with linear IgA disease. We have recently observed a patient suffering from ulcerative colitis who developed a cutaneous bullous eruption that was diagnosed as a linear IgA disease. Foreign antigens penetrating the inflamed bowel mucosa might give rise to the production of autoantibodies cross-reacting with the cutaneous antigens involved in the pathogenesis of linear IgA disease.
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