Mitoxantrone is an antineoplastic agent considered a potential human teratogen because of its mechanism of action and is classified by the US Food and Drug Administration in pregnancy category risk D. In the literature there are only four cases of women exposed to the drug in late pregnancy. We report the first case of mitoxantrone therapy in the first trimester and during the pregnancy. A 41-year-old woman affected with multiple sclerosis, conceived during therapy and continued mitoxantrone until 29 weeks and 3 days of her pregnancy. She delivered by cesarean section at 39 weeks a growth restricted female baby weighing 1950g without evidence of congenital malformations.

De Santis, M., Straface, G., Cavaliere, A. F., Rosati, P., Batocchi, A. P., Caruso, A., The first case of mitoxantrone exposure in early pregnancy, <<NEUROTOXICOLOGY>>, 2007; 28 (3): 696-697. [doi:10.1016/j.neuro.2006.10.002] [http://hdl.handle.net/10807/20172]

The first case of mitoxantrone exposure in early pregnancy

De Santis, Maria;Cavaliere, Anna Franca;Caruso, Alessandro
2007

Abstract

Mitoxantrone is an antineoplastic agent considered a potential human teratogen because of its mechanism of action and is classified by the US Food and Drug Administration in pregnancy category risk D. In the literature there are only four cases of women exposed to the drug in late pregnancy. We report the first case of mitoxantrone therapy in the first trimester and during the pregnancy. A 41-year-old woman affected with multiple sclerosis, conceived during therapy and continued mitoxantrone until 29 weeks and 3 days of her pregnancy. She delivered by cesarean section at 39 weeks a growth restricted female baby weighing 1950g without evidence of congenital malformations.
Inglese
De Santis, M., Straface, G., Cavaliere, A. F., Rosati, P., Batocchi, A. P., Caruso, A., The first case of mitoxantrone exposure in early pregnancy, <<NEUROTOXICOLOGY>>, 2007; 28 (3): 696-697. [doi:10.1016/j.neuro.2006.10.002] [http://hdl.handle.net/10807/20172]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/20172
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