The effects on red blood cells of superoxide dismutase (Cu,ZnSOD) depletion, induced by feeding Wistar rats with a copper deficient diet, were investigated. SOD depleted red blood cells were more sensitive to peroxidation and to hemolysis than normal cells when exposed to tert-butylhydroperoxide (t-BOOH). Membranes isolated from SOD depleted cells showed a lower content of vitamin E and higher (Na+, K+) and Mg2+ ATPase activities. These results support the view that superoxide dismutase plays an important role in cellular oxidative metabolism.

Palozza, P., Bartoli, G., Piccioni, E., Enhanced sensitivity to oxidative stress in Cu,ZnSOD depleted rat erythrocytes., <<BIOCHIMICA ET BIOPHYSICA ACTA>>, 1992; (1123): 291-295 [http://hdl.handle.net/10807/20157]

Enhanced sensitivity to oxidative stress in Cu,ZnSOD depleted rat erythrocytes.

Palozza, Paola;
1992

Abstract

The effects on red blood cells of superoxide dismutase (Cu,ZnSOD) depletion, induced by feeding Wistar rats with a copper deficient diet, were investigated. SOD depleted red blood cells were more sensitive to peroxidation and to hemolysis than normal cells when exposed to tert-butylhydroperoxide (t-BOOH). Membranes isolated from SOD depleted cells showed a lower content of vitamin E and higher (Na+, K+) and Mg2+ ATPase activities. These results support the view that superoxide dismutase plays an important role in cellular oxidative metabolism.
1992
Inglese
Palozza, P., Bartoli, G., Piccioni, E., Enhanced sensitivity to oxidative stress in Cu,ZnSOD depleted rat erythrocytes., <<BIOCHIMICA ET BIOPHYSICA ACTA>>, 1992; (1123): 291-295 [http://hdl.handle.net/10807/20157]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/20157
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact