The possibility of a cooperative interaction between fat-soluble antioxidants is examined in a membrane model. A combination of beta-carotene and alpha-tocopherol results in an inhibition of lipid peroxidation significantly greater than the sum of the individual inhibitions. Our data provide the first evidence that beta-carotene can act synergistically with alpha-tocopherol as an effective radical-trapping antioxidant in membranes.
Palozza, P., Krinsky, N., beta-Carotene and alpha-tocopherol are synergisticantioxidants., <<ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS>>, 1992; (297): 184-187 [http://hdl.handle.net/10807/20113]
beta-Carotene and alpha-tocopherol are synergistic antioxidants.
Palozza, Paola;
1992
Abstract
The possibility of a cooperative interaction between fat-soluble antioxidants is examined in a membrane model. A combination of beta-carotene and alpha-tocopherol results in an inhibition of lipid peroxidation significantly greater than the sum of the individual inhibitions. Our data provide the first evidence that beta-carotene can act synergistically with alpha-tocopherol as an effective radical-trapping antioxidant in membranes.
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