Optical neural networks process information at the speed of light and are energetically efficient. Photonic artificial intelligence allows speech recognition, image classification, and Ising machines. Modern machine learning paradigms, as extreme learning machines, reveal that disordered and biological materials may realize optical neural networks with thousands of nodes trained only at the input and at the readout. May we use living matter for machine learning? Here, we employ living three-dimensional tumor brain models to demonstrate a random optical learning machine (ROM) for the investigation of glioblastoma. The tumor spheroid act as a computational reservoir. The ROM detects cancer morphodynamics by laser-induced hyperthermia, quantifies chemotherapy, and cell metabolism. The ROM is a sensitive noninvasive smart probe for cytotoxicity assay and enables real-time investigation of tumor dynamics. We hence design and demonstrate a novel bio-hardware for optical computing and the study of light/complex matter interaction.

Pierangeli, D., Palmieri, V., Marcucci, G., Moriconi, C., Perini, G., De Spirito, M., Papi, M., Conti, C., Living optical random neural network with three dimensional tumor spheroids for cancer morphodynamics, <<COMMUNICATIONS PHYSICS>>, 2020; 3 (1): 1-10. [doi:10.1038/s42005-020-00428-9] [http://hdl.handle.net/10807/200348]

Living optical random neural network with three dimensional tumor spheroids for cancer morphodynamics

D.; Palmieri
Membro del Collaboration Group
;
C.; Perini;G.; De Spirito;M.; Papi
;
2020

Abstract

Optical neural networks process information at the speed of light and are energetically efficient. Photonic artificial intelligence allows speech recognition, image classification, and Ising machines. Modern machine learning paradigms, as extreme learning machines, reveal that disordered and biological materials may realize optical neural networks with thousands of nodes trained only at the input and at the readout. May we use living matter for machine learning? Here, we employ living three-dimensional tumor brain models to demonstrate a random optical learning machine (ROM) for the investigation of glioblastoma. The tumor spheroid act as a computational reservoir. The ROM detects cancer morphodynamics by laser-induced hyperthermia, quantifies chemotherapy, and cell metabolism. The ROM is a sensitive noninvasive smart probe for cytotoxicity assay and enables real-time investigation of tumor dynamics. We hence design and demonstrate a novel bio-hardware for optical computing and the study of light/complex matter interaction.
Inglese
Pierangeli, D., Palmieri, V., Marcucci, G., Moriconi, C., Perini, G., De Spirito, M., Papi, M., Conti, C., Living optical random neural network with three dimensional tumor spheroids for cancer morphodynamics, <<COMMUNICATIONS PHYSICS>>, 2020; 3 (1): 1-10. [doi:10.1038/s42005-020-00428-9] [http://hdl.handle.net/10807/200348]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/200348
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 5
  • ???jsp.display-item.citation.isi??? 3
social impact