Introduction: Psoriasis is a chronic, disabling, inflammatory skin disease whose pathogenesis still remains to be fully elucidated. Genetic and environmental factors induce an immune response mediated by several cytokines and chemokines, including IL-17A. Areas covered: Emerging evidence now suggests that IL-17A is central in the pathogenesis of psoriasis. Three agents neutralizing IL-17 (i.e., secukinumab and ixekizumab) or antagonizing its receptor (i.e., brodalumab) are in development and are being studied in Phase III clinical trials to evaluate their overall efficacy and safety. However, Phase II results of IL-17 blockade with each of these agents has shown a marked improvement of disease severity, thus confirming the pathogenic relevance of IL-17 in mediating crucial inflammatory circuits in psoriasis. Expert opinion: Anti-IL-17 agents are likely to become important future therapeutics in this disease and the may potentially impact on cardiovascular diseases, arthritis and other comorbidities associated with psoriasis. © 2013 Informa UK, Ltd.

Chiricozzi, A., Krueger, J. G., IL-17 targeted therapies for psoriasis, <<EXPERT OPINION ON INVESTIGATIONAL DRUGS>>, 2013; 22 (8): 993-1005. [doi:10.1517/13543784.2013.806483] [http://hdl.handle.net/10807/200305]

IL-17 targeted therapies for psoriasis

Chiricozzi, Andrea;
2013

Abstract

Introduction: Psoriasis is a chronic, disabling, inflammatory skin disease whose pathogenesis still remains to be fully elucidated. Genetic and environmental factors induce an immune response mediated by several cytokines and chemokines, including IL-17A. Areas covered: Emerging evidence now suggests that IL-17A is central in the pathogenesis of psoriasis. Three agents neutralizing IL-17 (i.e., secukinumab and ixekizumab) or antagonizing its receptor (i.e., brodalumab) are in development and are being studied in Phase III clinical trials to evaluate their overall efficacy and safety. However, Phase II results of IL-17 blockade with each of these agents has shown a marked improvement of disease severity, thus confirming the pathogenic relevance of IL-17 in mediating crucial inflammatory circuits in psoriasis. Expert opinion: Anti-IL-17 agents are likely to become important future therapeutics in this disease and the may potentially impact on cardiovascular diseases, arthritis and other comorbidities associated with psoriasis. © 2013 Informa UK, Ltd.
2013
Inglese
Chiricozzi, A., Krueger, J. G., IL-17 targeted therapies for psoriasis, <<EXPERT OPINION ON INVESTIGATIONAL DRUGS>>, 2013; 22 (8): 993-1005. [doi:10.1517/13543784.2013.806483] [http://hdl.handle.net/10807/200305]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/200305
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 137
  • ???jsp.display-item.citation.isi??? 129
social impact