Myasthenia gravis (MG) is a multifactorial autoimmune disease of the neuromuscular junction. We investigated the relation between four polymorphisms of the interleukin (IL)-1 gene cluster on 2q12-22, and MG susceptibility and clinical features in a large cohort of individuals. No polymorphism was associated with MG susceptibility. However, the IL-1A -889 CC genotype was associated with early disease onset (p=0.0044) in the whole MG group and the subgroup of CC males developed MG about 18 years earlier than males carrying other IL-1A -889 genotypes (p=0.022). This finding suggests that IL-1A is a disease modifier in MG, or is in linkage disequilibrium with an unknown locus on chromosome 2.

Sciacca, F., Ferri, C., Veglia, F., Andreetta, F., Mantegazza, R., Cornelio, F., Franciotta, D., Piccolo, G., Cosi, V., Batocchi, A. P., Evoli Stampanoni-B, A., Grimaldi, L., IL-1 genes in myasthenia gravis: IL-1A -889 polymorphism associated with sex and age of disease onset, <<JOURNAL OF NEUROIMMUNOLOGY>>, 2002; 122 (1-2): 94-99 [http://hdl.handle.net/10807/20014]

IL-1 genes in myasthenia gravis: IL-1A -889 polymorphism associated with sex and age of disease onset

Batocchi, Anna Paola;Evoli Stampanoni-B, Amelia;
2002

Abstract

Myasthenia gravis (MG) is a multifactorial autoimmune disease of the neuromuscular junction. We investigated the relation between four polymorphisms of the interleukin (IL)-1 gene cluster on 2q12-22, and MG susceptibility and clinical features in a large cohort of individuals. No polymorphism was associated with MG susceptibility. However, the IL-1A -889 CC genotype was associated with early disease onset (p=0.0044) in the whole MG group and the subgroup of CC males developed MG about 18 years earlier than males carrying other IL-1A -889 genotypes (p=0.022). This finding suggests that IL-1A is a disease modifier in MG, or is in linkage disequilibrium with an unknown locus on chromosome 2.
2002
Inglese
Sciacca, F., Ferri, C., Veglia, F., Andreetta, F., Mantegazza, R., Cornelio, F., Franciotta, D., Piccolo, G., Cosi, V., Batocchi, A. P., Evoli Stampanoni-B, A., Grimaldi, L., IL-1 genes in myasthenia gravis: IL-1A -889 polymorphism associated with sex and age of disease onset, <<JOURNAL OF NEUROIMMUNOLOGY>>, 2002; 122 (1-2): 94-99 [http://hdl.handle.net/10807/20014]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/20014
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