Myasthenia gravis (MG) is a multifactorial autoimmune disease of the neuromuscular junction. We investigated the relation between four polymorphisms of the interleukin (IL)-1 gene cluster on 2q12-22, and MG susceptibility and clinical features in a large cohort of individuals. No polymorphism was associated with MG susceptibility. However, the IL-1A -889 CC genotype was associated with early disease onset (p=0.0044) in the whole MG group and the subgroup of CC males developed MG about 18 years earlier than males carrying other IL-1A -889 genotypes (p=0.022). This finding suggests that IL-1A is a disease modifier in MG, or is in linkage disequilibrium with an unknown locus on chromosome 2.
Sciacca, F., Ferri, C., Veglia, F., Andreetta, F., Mantegazza, R., Cornelio, F., Franciotta, D., Piccolo, G., Cosi, V., Batocchi, A. P., Evoli Stampanoni-B, A., Grimaldi, L., IL-1 genes in myasthenia gravis: IL-1A -889 polymorphism associated with sex and age of disease onset, <<JOURNAL OF NEUROIMMUNOLOGY>>, 2002; 122 (1-2): 94-99 [http://hdl.handle.net/10807/20014]
IL-1 genes in myasthenia gravis: IL-1A -889 polymorphism associated with sex and age of disease onset
Batocchi, Anna Paola;Evoli Stampanoni-B, Amelia;
2002
Abstract
Myasthenia gravis (MG) is a multifactorial autoimmune disease of the neuromuscular junction. We investigated the relation between four polymorphisms of the interleukin (IL)-1 gene cluster on 2q12-22, and MG susceptibility and clinical features in a large cohort of individuals. No polymorphism was associated with MG susceptibility. However, the IL-1A -889 CC genotype was associated with early disease onset (p=0.0044) in the whole MG group and the subgroup of CC males developed MG about 18 years earlier than males carrying other IL-1A -889 genotypes (p=0.022). This finding suggests that IL-1A is a disease modifier in MG, or is in linkage disequilibrium with an unknown locus on chromosome 2.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
