Given that HIV-protease inhibitors (HIV-PIs) are substrates/inhibitors of the multidrug transporter ABCB1, can induce ABCB1 expression, and are used in combination with doxorubicin for AIDS-Kaposi's Sarcoma (KS) treatment, the role that ABCB1 plays in mediating multidrug resistance (MDR) in a fully transformed KS cell line (SLK) was explored.

Lucia, M. B. P., Anu, R., Handley, M., Gillet, J., Wu, C., De Donatis, G., Cauda, R., Gottesman, M., Exposure to HIV-protease inhibitors selects for increased expression of P-glycoprotein (ABCB1) in Kaposi's sarcoma cells, <<BRITISH JOURNAL OF CANCER>>, 2011; 105 (4): 513-522. [doi:10.1038/bjc.2011.275] [http://hdl.handle.net/10807/19959]

Exposure to HIV-protease inhibitors selects for increased expression of P-glycoprotein (ABCB1) in Kaposi's sarcoma cells

Lucia, Mothanje Barbara Patricia;Cauda, Roberto;
2011

Abstract

Given that HIV-protease inhibitors (HIV-PIs) are substrates/inhibitors of the multidrug transporter ABCB1, can induce ABCB1 expression, and are used in combination with doxorubicin for AIDS-Kaposi's Sarcoma (KS) treatment, the role that ABCB1 plays in mediating multidrug resistance (MDR) in a fully transformed KS cell line (SLK) was explored.
2011
Inglese
Lucia, M. B. P., Anu, R., Handley, M., Gillet, J., Wu, C., De Donatis, G., Cauda, R., Gottesman, M., Exposure to HIV-protease inhibitors selects for increased expression of P-glycoprotein (ABCB1) in Kaposi's sarcoma cells, <<BRITISH JOURNAL OF CANCER>>, 2011; 105 (4): 513-522. [doi:10.1038/bjc.2011.275] [http://hdl.handle.net/10807/19959]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/19959
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