During development, skeletal muscles adapt to stage-specific functional and metabolic challenges by switching the expression of specific subset of genes. The mechanism that governs these changes is still enigmatic. In a recent issue of Cell, Messina and coworkers shed light on this issue through the identification of a transcription factor—NFix—that coordinates the switch in gene expression at the transition from embryonic to fetal myoblasts.
Palacios, D., Puri, P. L., Switch NFix Developmental Myogenesis, <<DEVELOPMENTAL CELL>>, 2010; 18 (3): 340-341. [doi:10.1016/j.devcel.2010.03.005] [http://hdl.handle.net/10807/199488]
Switch NFix Developmental Myogenesis
Palacios, DanielaPrimo
;
2010
Abstract
During development, skeletal muscles adapt to stage-specific functional and metabolic challenges by switching the expression of specific subset of genes. The mechanism that governs these changes is still enigmatic. In a recent issue of Cell, Messina and coworkers shed light on this issue through the identification of a transcription factor—NFix—that coordinates the switch in gene expression at the transition from embryonic to fetal myoblasts.
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