Background: Progressive right heart chambers dilatation is frequent in the adult congenital heart disease (ACHD) population. We evaluated the immediate and mid-term response of right heart chambers to surgery performed in adulthood for lesions associated with right heart chambers enlargement. Methods: Thirty-six adult patients with lesions associated with right heart chambers enlargement submitted to surgery were studied. We collected echocardiographic data of right ventricle (RV) mid-diameter, right atrial volume indexed, RV systolic pressure, and tricuspid annular plane systolic excursion (TAPSE) prior to surgery (T0), at 2 to 5 days (T1), and 3 to 6 months (T2) after surgery. Results: At T1, we observed a significant decrease of RV mid-diameter (47.2 +/- 8.4 vs. 39.6 +/- 7.4 mm, P<.001), right atrial volume indexed (45.6 +/- 26.6 vs. 27.2 +/- 11 ml/m2, P<.001), and RV systolic pressure (39 +/- 14.8 vs. 32.8 +/- 11.3 mm Hg, P=.03). At T2, a further significant deviation in the rate of RV diameter (39.6 +/- 7.4 vs. 34.5 +/- 5.1 mm, P<.001), in RV systolic pressure (32.8 +/- 11.3 vs. 25.3 +/- 5 mm Hg, P=.03) and TAPSE (13.9 +/- 3.2 vs. 15.8 +/- 2.6 mm, P<.001) was observed. Conclusions: Positive right heart chambers remodeling occurs as early as in the immediate post-operative period in most ACHD patients operated for lesions associated with right heart chambers enlargement.

Panaioli, E., Graziani, F., Lillo, R., Delogu, A. B., Grandinetti, M., Di Molfetta, A., Perri, G., Pasquini, A., Colizzi, C., Lombardo, A., Locorotondo, G., Amodeo, A., Secinaro, A., Bruno, P., Lanza, G. A., Massetti, M., Early Right Heart Chambers Reverse Remodeling in Patients Operated in Adulthood for Congenital Lesions Associated with Right Heart Chambers Enlargement, <<WORLD JOURNAL FOR PEDIATRIC & CONGENITAL HEART SURGERY>>, 2021; 12 (6): 747-753. [doi:10.1177/21501351211040474] [http://hdl.handle.net/10807/199064]

Early Right Heart Chambers Reverse Remodeling in Patients Operated in Adulthood for Congenital Lesions Associated with Right Heart Chambers Enlargement

Graziani, Francesca;Lillo, Rosa;Delogu, Angelica Bibiana;Di Molfetta, Arianna;Perri, Gianluigi;Pasquini, Annalisa;Colizzi, Christian;Lombardo, Antonella;Locorotondo, Gabriella;Amodeo, Antonio;Bruno, Piergiorgio;Lanza, Gaetano Antonio;Massetti, Massimo
2021

Abstract

Background: Progressive right heart chambers dilatation is frequent in the adult congenital heart disease (ACHD) population. We evaluated the immediate and mid-term response of right heart chambers to surgery performed in adulthood for lesions associated with right heart chambers enlargement. Methods: Thirty-six adult patients with lesions associated with right heart chambers enlargement submitted to surgery were studied. We collected echocardiographic data of right ventricle (RV) mid-diameter, right atrial volume indexed, RV systolic pressure, and tricuspid annular plane systolic excursion (TAPSE) prior to surgery (T0), at 2 to 5 days (T1), and 3 to 6 months (T2) after surgery. Results: At T1, we observed a significant decrease of RV mid-diameter (47.2 +/- 8.4 vs. 39.6 +/- 7.4 mm, P<.001), right atrial volume indexed (45.6 +/- 26.6 vs. 27.2 +/- 11 ml/m2, P<.001), and RV systolic pressure (39 +/- 14.8 vs. 32.8 +/- 11.3 mm Hg, P=.03). At T2, a further significant deviation in the rate of RV diameter (39.6 +/- 7.4 vs. 34.5 +/- 5.1 mm, P<.001), in RV systolic pressure (32.8 +/- 11.3 vs. 25.3 +/- 5 mm Hg, P=.03) and TAPSE (13.9 +/- 3.2 vs. 15.8 +/- 2.6 mm, P<.001) was observed. Conclusions: Positive right heart chambers remodeling occurs as early as in the immediate post-operative period in most ACHD patients operated for lesions associated with right heart chambers enlargement.
Inglese
Panaioli, E., Graziani, F., Lillo, R., Delogu, A. B., Grandinetti, M., Di Molfetta, A., Perri, G., Pasquini, A., Colizzi, C., Lombardo, A., Locorotondo, G., Amodeo, A., Secinaro, A., Bruno, P., Lanza, G. A., Massetti, M., Early Right Heart Chambers Reverse Remodeling in Patients Operated in Adulthood for Congenital Lesions Associated with Right Heart Chambers Enlargement, <<WORLD JOURNAL FOR PEDIATRIC & CONGENITAL HEART SURGERY>>, 2021; 12 (6): 747-753. [doi:10.1177/21501351211040474] [http://hdl.handle.net/10807/199064]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/199064
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