A series of substituted pyrazolines were synthesized and evaluated for their anticancer activity and for their ability to inhibit P-glycoprotein-mediated multidrug resistance by direct binding to a purified protein domain containing an ATP-binding site and a modulator interacting region. Compounds 2a and e have been found to bind to P-glycoprotein with greater affinity

Manna, F., Chimenti, F., Fioravanti, R., Bolasco, A., Secci, D., Chimenti, P., Ferlini, C., Scambia, G., Synthesis of some pyrazole derivatives and preliminary investigation of their affinity binding to P-glycoprotein, <<BIOORGANIC & MEDICINAL CHEMISTRY LETTERS>>, 2005; (Ottobre): 4632-4635 [http://hdl.handle.net/10807/198371]

Synthesis of some pyrazole derivatives and preliminary investigation of their affinity binding to P-glycoprotein

Ferlini, Cristiano;Scambia, Giovanni
2005

Abstract

A series of substituted pyrazolines were synthesized and evaluated for their anticancer activity and for their ability to inhibit P-glycoprotein-mediated multidrug resistance by direct binding to a purified protein domain containing an ATP-binding site and a modulator interacting region. Compounds 2a and e have been found to bind to P-glycoprotein with greater affinity
eng
Manna, F., Chimenti, F., Fioravanti, R., Bolasco, A., Secci, D., Chimenti, P., Ferlini, C., Scambia, G., Synthesis of some pyrazole derivatives and preliminary investigation of their affinity binding to P-glycoprotein, <>, 2005; (Ottobre): 4632-4635 [http://hdl.handle.net/10807/198371]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/198371
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