Multiple sclerosis (MS) is a T-cell autoimmune disease of the central nervous system (CNS). Predominance of women in autoimmune diseases suggests that sex hormones may play a role in disease susceptibility. A possible role for prolactin, a neuroendocrine peptide with powerful immunomodulatory properties, is suggested in MS. We describe the case of a 32-year-old man affected by relapsing-remitting MS who experienced the first MS clinical event during the development of a prolactin-secreting adenoma and the only two MS relapses during adenoma recurrence. Prolactin may have facilitated the inflammatory process and triggered MS clinical attacks, suggesting a role of prolactin in immunomodulation and therefore in autoimmune disease course

Nociti, V., Frisullo, G., Tartaglione, T., Patanella, A. K., Iorio, R., Tonali, P. A., Batocchi, A. P., Multiple sclerosis attacks triggered by hyperprolactinemia, <<JOURNAL OF NEURO-ONCOLOGY>>, 2010; (Giugno): 407-409 [http://hdl.handle.net/10807/19703]

Multiple sclerosis attacks triggered by hyperprolactinemia

Nociti, Viviana;Frisullo, Giovanni;Tartaglione, Tommaso;Patanella, Agata Katia;Iorio, Raffaele;Batocchi, Anna Paola
2009

Abstract

Multiple sclerosis (MS) is a T-cell autoimmune disease of the central nervous system (CNS). Predominance of women in autoimmune diseases suggests that sex hormones may play a role in disease susceptibility. A possible role for prolactin, a neuroendocrine peptide with powerful immunomodulatory properties, is suggested in MS. We describe the case of a 32-year-old man affected by relapsing-remitting MS who experienced the first MS clinical event during the development of a prolactin-secreting adenoma and the only two MS relapses during adenoma recurrence. Prolactin may have facilitated the inflammatory process and triggered MS clinical attacks, suggesting a role of prolactin in immunomodulation and therefore in autoimmune disease course
Inglese
Nociti, V., Frisullo, G., Tartaglione, T., Patanella, A. K., Iorio, R., Tonali, P. A., Batocchi, A. P., Multiple sclerosis attacks triggered by hyperprolactinemia, <<JOURNAL OF NEURO-ONCOLOGY>>, 2010; (Giugno): 407-409 [http://hdl.handle.net/10807/19703]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/19703
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