Hypersensitivity reactions to carboplatin are rare but sometimes life-threatening events may occur requiring discontinuation of treatment. In our study, we describe clinical features and diagnostic procedures of carboplatin-associated reactions in children affected by low-grade astrocytoma and treated with multiple courses of carboplatin. In 6 out of 29 children, we reported allergic events. We also report a desensitization protocol for carboplatin administration, which allowed the patients to receive effective treatment without adverse reactions
Lazzareschi, I., Ruggiero, A., Riccardi, R., Colosimo, C., Attina, G., Lasorella, A., Hypersensitivity reaction to carboplatin in children, <<JOURNAL OF NEURO-ONCOLOGY>>, 2002; 58 (1): 33-37. [doi:10.1023/A:1015853200090] [http://hdl.handle.net/10807/19535]
Hypersensitivity reaction to carboplatin in children
Lazzareschi, Ilaria;Ruggiero, Antonio;Riccardi, Riccardo;Colosimo, Cesare;
2002
Abstract
Hypersensitivity reactions to carboplatin are rare but sometimes life-threatening events may occur requiring discontinuation of treatment. In our study, we describe clinical features and diagnostic procedures of carboplatin-associated reactions in children affected by low-grade astrocytoma and treated with multiple courses of carboplatin. In 6 out of 29 children, we reported allergic events. We also report a desensitization protocol for carboplatin administration, which allowed the patients to receive effective treatment without adverse reactions
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