Introduction: MRI is very accurate in selecting young women with cervical cancer for fertility-sparing surgery (FSS), in particular radical hysterectomy (RH). In order to improve obstetrical outcomes, neoadjuvant chemotherapy (NACT) followed by cold knife conization (CKC) has been proposed as alternative technique. Objective: To investigate the role of MRI in evaluation of response to treatment after neoadjuvant chemotherapy (NACT), followed by CKC, in patients with cervical cancer FIGO stage IB2-IIA1 with tumor size 2 – 4 cm, desiring to preserve their fertility. Methods: 13 young women (23–36 years old) with cervical cancer stage IB2-IIA1 desiring to preserve their fertility were included. Tumor diameter at baseline and after treatment was detected on 1.5 T MRI. Treatment response was assessed according to Response Evaluation Criteria in Solid Tumors (RECIST 1.1) and then compared to histopathology result. Results: MRI correctly assessed 11 out of 13 cases, according to RECIST 1.1, compared to histopathology. Among these 7 patients with partial response (PR), 2 cases of CR, 1 SD and 1 PD with persistence or enlargement of primary tumor. Conclusion: Our pilot study supports the usefulness of MRI in assessment of treatment response after NACT, followed by CKC. Trial registration number: ClinicalTrials.gov: NCT02323841

Russo, L., Gui, B., Micco, M., Panico, C., De Vincenzo, R., Fanfani, F., Scambia, G., Manfredi, R., The role of MRI in cervical cancer > 2 cm (FIGO stage IB2-IIA1) conservatively treated with neoadjuvant chemotherapy followed by conization: a pilot study, <<LA RADIOLOGIA MEDICA>>, 2021; 126 (8): 1055-1063. [doi:10.1007/s11547-021-01377-1] [http://hdl.handle.net/10807/193191]

The role of MRI in cervical cancer > 2 cm (FIGO stage IB2-IIA1) conservatively treated with neoadjuvant chemotherapy followed by conization: a pilot study

Russo L.;Gui B.;De Vincenzo R.;Fanfani F.;Scambia G.;Manfredi R.
2021

Abstract

Introduction: MRI is very accurate in selecting young women with cervical cancer for fertility-sparing surgery (FSS), in particular radical hysterectomy (RH). In order to improve obstetrical outcomes, neoadjuvant chemotherapy (NACT) followed by cold knife conization (CKC) has been proposed as alternative technique. Objective: To investigate the role of MRI in evaluation of response to treatment after neoadjuvant chemotherapy (NACT), followed by CKC, in patients with cervical cancer FIGO stage IB2-IIA1 with tumor size 2 – 4 cm, desiring to preserve their fertility. Methods: 13 young women (23–36 years old) with cervical cancer stage IB2-IIA1 desiring to preserve their fertility were included. Tumor diameter at baseline and after treatment was detected on 1.5 T MRI. Treatment response was assessed according to Response Evaluation Criteria in Solid Tumors (RECIST 1.1) and then compared to histopathology result. Results: MRI correctly assessed 11 out of 13 cases, according to RECIST 1.1, compared to histopathology. Among these 7 patients with partial response (PR), 2 cases of CR, 1 SD and 1 PD with persistence or enlargement of primary tumor. Conclusion: Our pilot study supports the usefulness of MRI in assessment of treatment response after NACT, followed by CKC. Trial registration number: ClinicalTrials.gov: NCT02323841
eng
Russo, L., Gui, B., Micco, M., Panico, C., De Vincenzo, R., Fanfani, F., Scambia, G., Manfredi, R., The role of MRI in cervical cancer > 2 cm (FIGO stage IB2-IIA1) conservatively treated with neoadjuvant chemotherapy followed by conization: a pilot study, <>, 2021; 126 (8): 1055-1063. [doi:10.1007/s11547-021-01377-1] [http://hdl.handle.net/10807/193191]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/193191
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