Using an immunoradiometric assay, Cathepsin D (Cath D) levels were measured in the cytosol of 23 normal and 39 neoplastic human laryngeal tissues. Scattered Cath D levels (from 2.2 to 17.8 pM/mg protein; median = 7.6) were found in normal mucosa specimens. Cath D concentrations range from 2.0 to 29.3 pM/mg protein (median = 8.5) in laryngeal tumors. When a comparison between Cath D levels in normal and neoplastic tissue specimens from the same patient was done, Cath D levels were significantly higher in laryngeal cancers than in their normal counterparts (P = 0.03). No correlation with clinico-pathological parameters and steroid hormone and epidermal growth factor receptor status was found. Further studies should investigate whether the production of Cath D by laryngeal tumors could have a clinical relevance for this neoplasia.

Ferrandina 1, G., Scambia, G., Benedetti Panici, P., Almadori, G., Paludetti, G., Cadoni, G., Distefano, M., Maurizi, M., Mancuso, S., Cathepsin D in primary squamous laryngeal tumors: correlation with clinico-pathological parameters and receptor status, <<CANCER LETTERS>>, 1992; 1992 (67): 133-138 [http://hdl.handle.net/10807/192622]

Cathepsin D in primary squamous laryngeal tumors: correlation with clinico-pathological parameters and receptor status

Scambia, G;Almadori, G;Paludetti, G;Cadoni, G;Maurizi, M;Mancuso, S
1992

Abstract

Using an immunoradiometric assay, Cathepsin D (Cath D) levels were measured in the cytosol of 23 normal and 39 neoplastic human laryngeal tissues. Scattered Cath D levels (from 2.2 to 17.8 pM/mg protein; median = 7.6) were found in normal mucosa specimens. Cath D concentrations range from 2.0 to 29.3 pM/mg protein (median = 8.5) in laryngeal tumors. When a comparison between Cath D levels in normal and neoplastic tissue specimens from the same patient was done, Cath D levels were significantly higher in laryngeal cancers than in their normal counterparts (P = 0.03). No correlation with clinico-pathological parameters and steroid hormone and epidermal growth factor receptor status was found. Further studies should investigate whether the production of Cath D by laryngeal tumors could have a clinical relevance for this neoplasia.
Inglese
Ferrandina 1, G., Scambia, G., Benedetti Panici, P., Almadori, G., Paludetti, G., Cadoni, G., Distefano, M., Maurizi, M., Mancuso, S., Cathepsin D in primary squamous laryngeal tumors: correlation with clinico-pathological parameters and receptor status, <<CANCER LETTERS>>, 1992; 1992 (67): 133-138 [http://hdl.handle.net/10807/192622]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/192622
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